COTL1 and ACTG1

Number of citations of the paper that reports this interaction (PMID 11297527)
20

Data Source:
BioGRID (pull down)

		COTL1	ACTG1
Gene Name		coactosin-like F-actin binding protein 1	actin gamma 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Nuclear Membrane Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Binding Enzyme Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Biological_process Defense Response To Fungus	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways			Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ACTA1 ACTB ACTG1 ALOX5 PDE6H TERF2IP	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		23406	71
HPRD ID		09482	00017
Ensembl ID		ENSG00000103187	ENSG00000184009
Uniprot IDs		Q14019	P63261
PDB IDs		1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
Enriched GO Terms of Interacting Partners?		Platelet Aggregation Retina Homeostasis Myofibril Assembly Adherens Junction Organization Ephrin Receptor Signaling Pathway Negative Regulation Of DNA Recombination At Telomere Leukotriene Production Involved In Inflammatory Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Skeletal Muscle Fiber Adaptation Striated Muscle Cell Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Muscle Cell Development Tissue Homeostasis Platelet Activation Cell Junction Assembly Cell-cell Junction Organization Protection From Non-homologous End Joining At Telomere Striated Muscle Cell Differentiation Telomere Capping Protein Localization To Chromosome, Telomeric Region Multicellular Organismal Homeostasis Skeletal Muscle Thin Filament Assembly Response To Stimulus Phagocytosis Lipoxin Metabolic Process Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Skeletal Myofibril Assembly Skeletal Muscle Adaptation Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Muscle Cell Differentiation Homotypic Cell-cell Adhesion Defense Response Lipoxygenase Pathway Homeostatic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Immune Response-regulating Cell Surface Receptor Signaling Pathway Organelle Organization Axon Guidance Movement Of Cell Or Subcellular Component Blood Coagulation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Hemostasis Regulation Of Telomere Maintenance Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Stress	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?		anxa2 biogenesis breeding cdna chicken chickens coactosin constructed country differentially eef2 egg excluding glands house l2 laying microarray mx ocx overlapping ovocalyxin redundant representing semi shell sox18 taiwanese transcripts	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		anxa2 biogenesis breeding cdna chicken chickens coactosin constructed country differentially eef2 egg excluding glands house l2 laying microarray mx ocx overlapping ovocalyxin redundant representing semi shell sox18 taiwanese transcripts	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?