AIF1 and ACTA1

Number of citations of the paper that reports this interaction (PMID 12714565)
9

Data Source:
HPRD (in vitro, in vivo)

		AIF1	ACTA1
Gene Name		allograft inflammatory factor 1	actin, alpha 1, skeletal muscle
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Nucleus Cytoplasm Cytosol Actin Filament Lamellipodium Ruffle Membrane Perikaryon Perinuclear Region Of Cytoplasm	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Molecular_function Calcium Ion Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Phagocytosis, Engulfment Inflammatory Response Negative Regulation Of Gene Expression Positive Regulation Of Muscle Hyperplasia Rac Protein Signal Transduction Actin Filament Polymerization Cellular Response To Extracellular Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Actin Filament Bundle Assembly Response To Electrical Stimulus Cellular Response To Morphine Cellular Response To Interferon-gamma Cellular Response To Hydroperoxide Negative Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Monocyte Chemotaxis Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T Cell Migration	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Crohn's disease ( 22936669) Height ( 23563607) Neonatal lupus ( 20662065) Weight ( 19079260)
Protein-Protein Interactions		2 interactors: ACTA1 LCP1	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		199	58
HPRD ID		03496	00030
Ensembl ID		ENSG00000204472	ENSG00000143632
Uniprot IDs		I3WTX1 P55008 Q4V347	P68133 Q5T8M7
PDB IDs		2D58 2G2B	1T44
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Fiber Adaptation Actin Filament Organization Protein Kinase A Signaling Skeletal Muscle Thin Filament Assembly Actin Cytoskeleton Organization Skeletal Myofibril Assembly Skeletal Muscle Adaptation Actin Filament-based Process Skeletal Muscle Fiber Development Cytoskeleton Organization Myotube Cell Development Response To Lithium Ion Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Movement Of Cell Or Subcellular Component Muscle Fiber Development Myotube Differentiation Actin Filament-based Movement Actin Filament Bundle Assembly T Cell Activation Involved In Immune Response Organ Regeneration Cellular Component Assembly Myofibril Assembly Actomyosin Structure Organization Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Cell Growth Leukocyte Activation Involved In Immune Response Striated Muscle Cell Development Muscle Cell Development Organ Development Organelle Organization Response To Mechanical Stimulus Muscle Contraction Striated Muscle Cell Differentiation Regulation Of Intracellular Protein Transport Muscle System Process Muscle Organ Development T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Striated Muscle Tissue Development Leukocyte Cell-cell Adhesion Muscle Cell Differentiation Response To Metal Ion Homotypic Cell-cell Adhesion Muscle Tissue Development	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		3xmyc assigned athanogene bag6 bcl2 bioinformatics classes elucidating highlighted immunoprecipitated infectious insertion interactome interested involve kegg lc locations marc nonstructural nsp2 ontology porcine prrsv replication reproductive subcellular tag transporting	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		3xmyc assigned athanogene bag6 bcl2 bioinformatics classes elucidating highlighted immunoprecipitated infectious insertion interactome interested involve kegg lc locations marc nonstructural nsp2 prrsv replication reproductive subcellular tag transporting	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized pfam pig pituitary singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?		ontology porcine