AIF1 and LCP1

Number of citations of the paper that reports this interaction (PMID 14756805)
19

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		AIF1	LCP1
Gene Name		allograft inflammatory factor 1	lymphocyte cytosolic protein 1 (L-plastin)
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Nucleus Cytoplasm Cytosol Actin Filament Lamellipodium Ruffle Membrane Perikaryon Perinuclear Region Of Cytoplasm	Stress Fiber Ruffle Phagocytic Cup Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Filopodium Actin Filament Bundle Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Calcium Ion Binding Actin Filament Binding	Actin Binding Calcium Ion Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Phagocytosis, Engulfment Inflammatory Response Negative Regulation Of Gene Expression Positive Regulation Of Muscle Hyperplasia Rac Protein Signal Transduction Actin Filament Polymerization Cellular Response To Extracellular Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Actin Filament Bundle Assembly Response To Electrical Stimulus Cellular Response To Morphine Cellular Response To Interferon-gamma Cellular Response To Hydroperoxide Negative Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Monocyte Chemotaxis Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T Cell Migration	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Organ Regeneration Regulation Of Intracellular Protein Transport Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 22936669) Height ( 23563607) Neonatal lupus ( 20662065) Weight ( 19079260)	Non-alcoholic fatty liver disease histology (other) ( 23213074)
Protein-Protein Interactions		2 interactors: ACTA1 LCP1	5 interactors: AIF1 ATXN2 CNN3 GCA PRKACA
Entrez ID		199	3936
HPRD ID		03496	01082
Ensembl ID		ENSG00000204472	ENSG00000136167
Uniprot IDs		I3WTX1 P55008 Q4V347	P13796
PDB IDs		2D58 2G2B	2D85
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Fiber Adaptation Actin Filament Organization Protein Kinase A Signaling Skeletal Muscle Thin Filament Assembly Actin Cytoskeleton Organization Skeletal Myofibril Assembly Skeletal Muscle Adaptation Actin Filament-based Process Skeletal Muscle Fiber Development Cytoskeleton Organization Myotube Cell Development Response To Lithium Ion Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Movement Of Cell Or Subcellular Component Muscle Fiber Development Myotube Differentiation Actin Filament-based Movement Actin Filament Bundle Assembly T Cell Activation Involved In Immune Response Organ Regeneration Cellular Component Assembly Myofibril Assembly Actomyosin Structure Organization Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Cell Growth Leukocyte Activation Involved In Immune Response Striated Muscle Cell Development Muscle Cell Development Organ Development Organelle Organization Response To Mechanical Stimulus Muscle Contraction Striated Muscle Cell Differentiation Regulation Of Intracellular Protein Transport Muscle System Process Muscle Organ Development T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Striated Muscle Tissue Development Leukocyte Cell-cell Adhesion Muscle Cell Differentiation Response To Metal Ion Homotypic Cell-cell Adhesion Muscle Tissue Development	Positive Regulation Of Muscle Hyperplasia Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Chemotaxis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Behavior Regulation Of Chemotaxis Histone H3-T6 Phosphorylation Negative Regulation Of Smooth Muscle Cell Chemotaxis Membrane Organization Regulation Of Behavior Positive Regulation Of Smooth Muscle Cell Chemotaxis Cellular Response To Morphine Positive Regulation Of Cell Cycle Process Cellular Response To Isoquinoline Alkaloid Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Cell Cycle Organelle Organization Positive Regulation Of Cell Migration Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Negative Regulation Of Receptor Internalization Regulation Of Tight Junction Assembly Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Glucose Import Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Response To Parathyroid Hormone Negative Regulation Of Transport Cellular Response To Organic Cyclic Compound Phagocytosis, Engulfment Positive Regulation Of Protein Export From Nucleus Microglial Cell Activation Regulation Of Mitotic Cell Cycle Regulation Of Monocyte Chemotaxis Cerebellar Purkinje Cell Differentiation Cell Communication By Electrical Coupling Cellular Response To Hydroperoxide Activation Of Protein Kinase A Activity Stress Granule Assembly
Tagcloud ?		3xmyc assigned athanogene bag6 bcl2 bioinformatics classes elucidating highlighted immunoprecipitated infectious insertion interactome interested involve kegg lc locations marc nonstructural nsp2 ontology porcine prrsv replication reproductive subcellular tag transporting	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		3xmyc assigned athanogene bag6 bcl2 bioinformatics classes elucidating highlighted immunoprecipitated infectious insertion interactome interested involve kegg lc locations marc nonstructural nsp2 ontology porcine prrsv replication reproductive subcellular tag transporting	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?