USP37 and RHOU

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		USP37	RHOU
Description		ubiquitin specific peptidase 37	ras homolog family member U
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Deubiquitinase Activity	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Proteolysis Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Cell Division Protein K48-linked Deubiquitination	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Ub-specific processing proteases	Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 25673413) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Male-pattern baldness ( 28196072) Post bronchodilator FEV1/FVC ratio ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172)	Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		8 interacting genes: ATM AURKB BLM CCNA2 MYC RHOU UBC YWHAG	126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		57695	58480
HPRD ID		07506	06965
Ensembl ID		ENSG00000135913	ENSG00000116574
Uniprot IDs		Q86T82	Q7L0Q8
PDB IDs		3U12	2Q3H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Division Cellular Response To Radiation Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Telomere Maintenance Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Response To Alkaloid Post-translational Protein Modification Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Response To Radiation Mitotic Cell Cycle Phase Transition Regulation Of B Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Double-strand Break Processing Negative Regulation Of Immune System Process Regulation Of Cell Division Response To X-ray Modification-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Alkaloid Spindle Chromosome Regulation Of Chromosome Organization Proteolysis Involved In Protein Catabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of Fibroblast Proliferation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Lymphocyte Apoptotic Process Protein Modification Process Regulation Of Mitotic Sister Chromatid Separation Signal Transduction	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin
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