USP37

Description		ubiquitin specific peptidase 37
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Deubiquitinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Proteolysis Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Cell Division Protein K48-linked Deubiquitination
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Body mass index ( 25673413) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Male-pattern baldness ( 28196072) Post bronchodilator FEV1/FVC ratio ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: ATM AURKB BLM CCNA2 MYC RHOU UBC YWHAG
Entrez ID		57695
HPRD ID		07506
Ensembl ID		ENSG00000135913
Uniprot IDs		Q86T82
PDB IDs		3U12
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Division Cellular Response To Radiation Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Telomere Maintenance Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Response To Alkaloid Post-translational Protein Modification Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Response To Radiation Mitotic Cell Cycle Phase Transition Regulation Of B Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Double-strand Break Processing Negative Regulation Of Immune System Process Regulation Of Cell Division Response To X-ray Modification-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Alkaloid Spindle Chromosome Regulation Of Chromosome Organization Proteolysis Involved In Protein Catabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of Fibroblast Proliferation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Lymphocyte Apoptotic Process Protein Modification Process Regulation Of Mitotic Sister Chromatid Separation Signal Transduction
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