USP37 and BLM

Number of citations of the paper that reports this interaction (PubMedID 34606619)
76

Data Source:
BioGRID (pull down)

		USP37	BLM
Description		ubiquitin specific peptidase 37	BLM RecQ like helicase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body RecQ Family Helicase-topoisomerase III Complex Protein-containing Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Deubiquitinase Activity	Nucleotide Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding P53 Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Four-way Junction Helicase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Metal Ion Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding DNA/DNA Annealing Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Proteolysis Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Cell Division Protein K48-linked Deubiquitination	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair DNA Recombination DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA Recombination Protein Complex Oligomerization Protein Homooligomerization Negative Regulation Of Cell Division Telomeric D-loop Disassembly Resolution Of DNA Recombination Intermediates Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin T-circle Formation
Pathways		Ub-specific processing proteases	Processive synthesis on the C-strand of the telomere SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Body mass index ( 25673413) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Male-pattern baldness ( 28196072) Post bronchodilator FEV1/FVC ratio ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172)	Coronary artery disease ( 32469254) Daytime sleep phenotypes ( 27126917)
Interacting Genes		8 interacting genes: ATM AURKB BLM CCNA2 MYC RHOU UBC YWHAG	39 interacting genes: ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 DNA2 EXO1 FANCD2 FBXW7 FEN1 JUN MCRS1 MIB1 MLH1 MX1 NEK11 PSMD3 RAD51 RAD51D RNF4 RNF8 RPA1 SMC1A SPIDR SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TP53 TP53BP1 TRIM49 UBE2I UPF2 USP37 WRN
Entrez ID		57695	641
HPRD ID		07506	05211
Ensembl ID		ENSG00000135913	ENSG00000197299
Uniprot IDs		Q86T82	B7ZKN7 H0YNU5 P54132
PDB IDs		3U12	2KV2 2MH9 2RRD 3WE2 3WE3 4CDG 4CGZ 4O3M 5LUP 5MK5 5U6K 7AUC 7AUD 7XUW 7XV0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Division Cellular Response To Radiation Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Telomere Maintenance Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Response To Alkaloid Post-translational Protein Modification Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Response To Radiation Mitotic Cell Cycle Phase Transition Regulation Of B Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Double-strand Break Processing Negative Regulation Of Immune System Process Regulation Of Cell Division Response To X-ray Modification-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Alkaloid Spindle Chromosome Regulation Of Chromosome Organization Proteolysis Involved In Protein Catabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of Fibroblast Proliferation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Lymphocyte Apoptotic Process Protein Modification Process Regulation Of Mitotic Sister Chromatid Separation Signal Transduction	DNA Damage Response DNA Repair DNA Metabolic Process Chromosome Organization Cellular Response To Stress Double-strand Break Repair Macromolecule Metabolic Process Chromosome, Telomeric Region PML Body Nucleic Acid Metabolic Process Nucleoplasm Response To Stress Telomere Maintenance Regulation Of DNA Metabolic Process DNA Recombination Telomere Organization Regulation Of Cell Cycle Chromosome Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Nucleus Negative Regulation Of Cell Cycle Process Positive Regulation Of DNA Metabolic Process Response To Ionizing Radiation Regulation Of Cell Cycle Process Replication Fork Signal Transduction In Response To DNA Damage Response To Radiation Regulation Of DNA Replication Interstrand Cross-link Repair Nuclear Body Chromosome Organization Involved In Meiotic Cell Cycle DNA Damage Checkpoint Signaling Organelle Organization Nuclear Chromosome T-circle Formation Cellular Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Replicative Senescence Regulation Of DNA Recombination Recombinational Repair Replication Fork Processing DNA Replication Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Regulation Of Chromosome Organization Condensed Nuclear Chromosome Chromatin Binding
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