USP37 and AURKB

Number of citations of the paper that reports this interaction (PubMedID 34509474)
60

Data Source:
BioGRID (pull down)

		USP37	AURKB
Description		ubiquitin specific peptidase 37	aurora kinase B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Deubiquitinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Proteolysis Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Cell Division Protein K48-linked Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of B Cell Apoptotic Process Spindle Organization Mitotic Spindle Organization Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Telomere Maintenance Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Microtubule-based Process Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Post-translational Protein Modification Cell Cycle G2/M Phase Transition Mitotic Cytokinesis Checkpoint Signaling Negative Regulation Of Innate Immune Response Mitotic Spindle Midzone Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Midbody Abscission Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Repair Of Mitotic Kinetochore Microtubule Attachment Defect CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Biorientation
Pathways		Ub-specific processing proteases	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation
Drugs			Hesperidin AT9283 Enzastaurin Reversine Fostamatinib TAK-901
Diseases
GWAS		Body mass index ( 25673413) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Male-pattern baldness ( 28196072) Post bronchodilator FEV1/FVC ratio ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172)	Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)
Interacting Genes		8 interacting genes: ATM AURKB BLM CCNA2 MYC RHOU UBC YWHAG	57 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CDH1 CENPA CIB1 DCUN1D1 DES EVI5 FBXL2 FLOT1 GANAB GAS2L3 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LIN28B LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SHCBP1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I USP37
Entrez ID		57695	9212
HPRD ID		07506	05397
Ensembl ID		ENSG00000135913	ENSG00000178999
Uniprot IDs		Q86T82	Q96GD4
PDB IDs		3U12	4AF3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Division Cellular Response To Radiation Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Telomere Maintenance Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Response To Alkaloid Post-translational Protein Modification Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Response To Radiation Mitotic Cell Cycle Phase Transition Regulation Of B Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Double-strand Break Processing Negative Regulation Of Immune System Process Regulation Of Cell Division Response To X-ray Modification-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Alkaloid Spindle Chromosome Regulation Of Chromosome Organization Proteolysis Involved In Protein Catabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of Fibroblast Proliferation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Lymphocyte Apoptotic Process Protein Modification Process Regulation Of Mitotic Sister Chromatid Separation Signal Transduction	Cell Division Spindle Spindle Organization Cytoskeleton Microtubule Cytoskeleton Organization Spindle Assembly Cytoskeleton Organization Regulation Of Chromosome Separation Microtubule-based Process Regulation Of Cell Cycle Midbody Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Microtubule Binding Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Organelle Organization Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Nuclear Chromosome Segregation Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Positive Regulation Of Chromosome Separation Membraneless Organelle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Cellular Component Organization Chromosome, Centromeric Region Regulation Of Organelle Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Process Microtubule Cytoskeleton Regulation Of Protein-containing Complex Assembly Mitotic Spindle Midzone Assembly Regulation Of Cytokinesis Mitotic Cell Cycle Centrosome Cytoskeleton-dependent Cytokinesis Regulation Of Nuclear Division Mitotic Spindle Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Metaphase Chromosome Alignment Spindle Midzone Assembly Spindle Assembly Involved In Female Meiosis Mitotic Cytokinesis
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