USP28 and UCHL5

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP28	UCHL5
Gene Name		ubiquitin specific peptidase 28	ubiquitin carboxyl-terminal hydrolase L5
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Protein Complex	Proteasome Complex Nucleus Cytosol Ino80 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Cannabis dependence ( 21668797)
Protein-Protein Interactions		33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1
Entrez ID		57646	51377
HPRD ID		15632	10293
Ensembl ID		ENSG00000048028	ENSG00000116750
Uniprot IDs		B4E3L3 Q96RU2	Q9Y5K5
PDB IDs		2LVA	3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process	Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process
Tagcloud ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Difference) ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Intersection) ?