USP28 and ESPL1

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP28	ESPL1
Gene Name		ubiquitin specific peptidase 28	extra spindle pole bodies homolog 1 (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Protein Complex	Nucleus Centrosome Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding	Catalytic Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cell Cycle Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion
Pathways			Separation of Sister Chromatids Mitotic Anaphase Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	6 interactors: PJA1 RFFL TRIM55 TRIM63 USP21 USP28
Entrez ID		57646	9700
HPRD ID		15632	06825
Ensembl ID		ENSG00000048028	ENSG00000135476
Uniprot IDs		B4E3L3 Q96RU2	Q14674
PDB IDs		2LVA
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process	Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Modification Process Protein Ubiquitination Protein Deubiquitination Protein Modification By Small Protein Conjugation Protein Modification By Small Protein Removal Regulation Of Proteolysis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Negative Regulation Of Execution Phase Of Apoptosis Skeletal Muscle Adaptation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Histone Deubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Response To Dexamethasone Stimulus Regulation Of Fibroblast Migration Response To Dexamethasone Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Response To Electrical Stimulus Regulation Of Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus
Tagcloud ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Difference) ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Intersection) ?