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USP28 and MDC1
Number of citations of the paper that reports this interaction (PubMedID
16901786
)
0
Data Source:
HPRD
(in vivo)
USP28
MDC1
Description
ubiquitin specific peptidase 28
mediator of DNA damage checkpoint 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Nuclear Body
Protein-containing Complex
Nucleus
Nucleoplasm
Chromosome
Focal Adhesion
Nuclear Body
Site Of Double-strand Break
Molecular Function
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Deubiquitinase Activity
Protein Binding
Chromatin-protein Adaptor Activity
Histone Reader Activity
Biological Process
DNA Damage Checkpoint Signaling
DNA Repair
Proteolysis
DNA Damage Response
Cell Population Proliferation
Response To Ionizing Radiation
Protein Deubiquitination
Regulation Of Protein Stability
Cellular Response To UV
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
DNA Replication Checkpoint Signaling
DNA Repair
Chromatin Organization
DNA Damage Response
Mitotic Intra-S DNA Damage Checkpoint Signaling
Protein K6-linked Ubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Pathways
Ub-specific processing proteases
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
TP53 Regulates Transcription of DNA Repair Genes
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Alcohol consumption (drinks per week) (
30643258
)
Low density lipoprotein cholesterol levels (
32154731
)
PR interval (
32439900
)
Autism spectrum disorder or schizophrenia (
28540026
)
Eosinophil count (
31272903
)
Interacting Genes
43 interacting genes:
ATXN3L
BAP1
CDC73
CFTR
CLSPN
ESPL1
HIF1A
JOSD1
KDM1A
MAP3K1
MDC1
MTNR1A
NSMCE2
OTUB1
OTUB2
PJA1
PLA2G2A
PRKD1
RFFL
SENP1
SENP8
STAM
STAMBP
SUMO2
TP53
TP53BP1
TRIM55
TRIM63
TTC3
UBC
UCHL1
UCHL3
UCHL5
USP14
USP15
USP20
USP21
USP33
USP4
USP5
USP51
USP7
USP8
42 interacting genes:
ANAPC1
ATM
BARD1
BDKRB1
BRCA1
CASP3
CENPC
CHEK2
COPS5
CREBBP
CSNK2A1
DTX2
EP300
GATA4
H2AX
HDAC10
HDAC8
HINFP
NBN
NCL
NSD2
PIAS1
PIAS4
PRIM1
PTEN
RAD50
RAD51
RNF8
SMC1A
SRPK2
SUMO2
TNKS2
TP53
TP53BP1
UIMC1
USP13
USP15
USP28
USP7
VAMP5
WRN
ZNF251
Entrez ID
57646
9656
HPRD ID
15632
16252
Ensembl ID
ENSG00000048028
ENSG00000137337
Uniprot IDs
A0A8V8TLZ9
B4E3L3
Q96RU2
A0A1U9XBC1
A0A1U9XBE3
A0A1U9XBF2
A1Z5I9
Q14676
PDB IDs
2LVA
2MUU
6H4H
6H4I
6HEH
6HEI
6HEJ
6HEK
7TUO
8HJE
8P14
8P19
8P1P
8P1Q
2ADO
2AZM
2ETX
3K05
3UEO
3UMZ
3UN0
3UNM
3UNN
3UOT
9IF9
Enriched GO Terms of Interacting Partners
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Protein Modification By Small Protein Removal
Protein Deubiquitination
Cysteine-type Peptidase Activity
Cysteine-type Deubiquitinase Activity
Post-translational Protein Modification
Protein Modification Process
Peptidase Activity
Protein Metabolic Process
Proteolysis
Macromolecule Metabolic Process
Protein K48-linked Deubiquitination
Cysteine-type Endopeptidase Activity
Deubiquitinase Activity
Hydrolase Activity
DeNEDDylase Activity
Protein K63-linked Deubiquitination
Ubiquitin Binding
Protein Modification By Small Protein Conjugation
Modification-dependent Protein Catabolic Process
P53 Binding
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Protein Catabolic Process
Regulation Of Cellular Response To Stress
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Catabolic Process
Macromolecule Catabolic Process
Cytosol
Monoubiquitinated Protein Deubiquitination
Negative Regulation Of Proteolysis
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of TOR Signaling
Protein Ubiquitination
Negative Regulation Of TOR Signaling
Regulation Of DNA Metabolic Process
Regulation Of Protein Catabolic Process
Negative Regulation Of Catabolic Process
Regulation Of Proteolysis
DNA Repair
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Chromatin Organization
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Ubiquitin Protein Ligase Binding
K63-linked Deubiquitinase Activity
K48-linked Deubiquitinase Activity
DNA Repair
DNA Damage Response
DNA Metabolic Process
Double-strand Break Repair
Regulation Of Cellular Response To Stress
Nucleoplasm
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Response To Ionizing Radiation
Response To Radiation
Negative Regulation Of Cell Cycle Phase Transition
Cellular Response To Stress
DNA Damage Checkpoint Signaling
Post-translational Protein Modification
Signal Transduction In Response To DNA Damage
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Positive Regulation Of DNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
DNA Recombination
Nucleic Acid Metabolic Process
Regulation Of DNA Recombination
Nucleus
Regulation Of Double-strand Break Repair
Regulation Of Cell Cycle Phase Transition
Chromatin Remodeling
PML Body
Macromolecule Metabolic Process
Protein Modification Process
Chromatin Organization
Cellular Response To Radiation
Regulation Of Double-strand Break Repair Via Homologous Recombination
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of DNA Repair
Recombinational Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Site Of Double-strand Break
Regulation Of Primary Metabolic Process
Homologous Recombination
Ubiquitin-modified Histone Reader Activity
Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Process
Cellular Response To Ionizing Radiation
Positive Regulation Of DNA Recombination
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