USP28 and USP51

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP28	USP51
Gene Name		ubiquitin specific peptidase 28	ubiquitin specific peptidase 51
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Protein Complex	SAGA Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Zinc Ion Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Transcription, DNA-templated Histone Deubiquitination Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	4 interactors: PJA1 USP15 USP21 USP28
Entrez ID		57646	158880
HPRD ID		15632	07167
Ensembl ID		ENSG00000048028	ENSG00000247746
Uniprot IDs		B4E3L3 Q96RU2	Q70EK9
PDB IDs		2LVA
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process	Protein Deubiquitination Protein Catabolic Process Protein Modification By Small Protein Removal Regulation Of Proteasomal Protein Catabolic Process Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteolysis Cellular Macromolecule Catabolic Process Histone H2B Conserved C-terminal Lysine Deubiquitination Cellular Protein Modification Process Proteolysis Cellular Protein Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification Regulation Of Cellular Protein Metabolic Process Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Chromatin Modification Chromatin Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV Chromosome Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Cellular Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Difference) ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Intersection) ?