USP28 and USP15

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		USP28	USP15
Description		ubiquitin specific peptidase 28	ubiquitin specific peptidase 15
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity	Catalytic Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin-modified Histone Reader Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Proteolysis DNA Damage Response Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Transcription Elongation-coupled Chromatin Remodeling Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination
Pathways		Ub-specific processing proteases	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		43 interacting genes: ATXN3L BAP1 CDC73 CFTR CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 TTC3 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	61 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDC73 CSNK1A1 FHL1 GEMIN4 GLUL GOLGA2 GOLGA6A GSPT1 H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PARP1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RIGI RNF126 RNF144B RNF26 SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		57646	9958
HPRD ID		15632	05293
Ensembl ID		ENSG00000048028	ENSG00000135655
Uniprot IDs		A0A8V8TLZ9 B4E3L3 Q96RU2	Q9Y4E8
PDB IDs		2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK 7TUO 8HJE 8P14 8P19 8P1P 8P1Q	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1 7R2G
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Post-translational Protein Modification Protein Modification Process Peptidase Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Protein K48-linked Deubiquitination Cysteine-type Endopeptidase Activity Deubiquitinase Activity Hydrolase Activity DeNEDDylase Activity Protein K63-linked Deubiquitination Ubiquitin Binding Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process P53 Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Catabolic Process Cytosol Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of TOR Signaling Protein Ubiquitination Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis DNA Repair Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin Protein Ligase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Post-translational Protein Modification Protein Modification Process Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Cysteine-type Peptidase Activity Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Peptidase Activity Protein K48-linked Deubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity DeNEDDylase Activity Catabolic Process Zinc Ion Binding Cytosol Protein Polyubiquitination Proteasomal Protein Catabolic Process Cytoplasm Deubiquitinase Activity Protein Catabolic Process Innate Immune Response Ubiquitin Binding Cysteine-type Endopeptidase Activity Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Transferase Activity Defense Response To Symbiont Metal Ion Binding Defense Response To Other Organism Response To External Biotic Stimulus Response To Stress Response To Other Organism Hydrolase Activity Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Regulation Of Signal Transduction Antiviral Innate Immune Response Regulation Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Regulation Of Double-strand Break Repair
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