USP28 and NSMCE2

Number of citations of the paper that reports this interaction (PubMedID 25359778)
48

Data Source:
BioGRID (enzymatic study)

		USP28	NSMCE2
Description		ubiquitin specific peptidase 28	NSE2 SUMO ligase component of SMC5/6 complex
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nuclear Body PML Body Smc5-Smc6 Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity	Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Proteolysis DNA Damage Response Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence Chromatin Looping
Pathways		Ub-specific processing proteases	SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)	A body shape index ( 34021172) Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		43 interacting genes: ATXN3L BAP1 CDC73 CFTR CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 TTC3 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28
Entrez ID		57646	286053
HPRD ID		15632	08131
Ensembl ID		ENSG00000048028	ENSG00000156831
Uniprot IDs		A0A8V8TLZ9 B4E3L3 Q96RU2	A0A087WTZ8 Q96MF7
PDB IDs		2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK 7TUO 8HJE 8P14 8P19 8P1P 8P1Q	2YU4
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Post-translational Protein Modification Protein Modification Process Peptidase Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Protein K48-linked Deubiquitination Cysteine-type Endopeptidase Activity Deubiquitinase Activity Hydrolase Activity DeNEDDylase Activity Protein K63-linked Deubiquitination Ubiquitin Binding Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process P53 Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Catabolic Process Cytosol Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of TOR Signaling Protein Ubiquitination Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis DNA Repair Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin Protein Ligase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Single-stranded DNA Binding Endoribonuclease Complex A2A Adenosine Receptor Binding DNA Secondary Structure Binding Interchromatin Granule Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Sex Chromosome Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process SiRNA Processing Smc5-Smc6 Complex
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