USP28 and USP14

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP28	USP14
Gene Name		ubiquitin specific peptidase 28	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Protein Complex	Proteasome Complex Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Synapse Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding TRNA Guanylyltransferase Activity Proteasome Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Synaptic Transmission Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	7 interactors: COPS5 CXCR4 FANCC UBC USP15 USP21 USP28
Entrez ID		57646	9097
HPRD ID		15632	06279
Ensembl ID		ENSG00000048028	ENSG00000101557
Uniprot IDs		B4E3L3 Q96RU2	B7Z4N8 P54578
PDB IDs		2LVA	2AYN 2AYO
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process	Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone Deubiquitination Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Proteolysis Cellular Macromolecule Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator DNA Repair Regulation Of MAPK Cascade Histone H2B Conserved C-terminal Lysine Deubiquitination Activation Of MAPK Activity Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process DNA Damage Checkpoint Catabolic Process Exosomal Secretion Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Viral Life Cycle Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Positive Regulation Of MAP Kinase Activity Cell Cycle Checkpoint Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Germ Cell Development Programmed Cell Death Cullin Deneddylation Cell Death Death Activation Of Protein Kinase Activity Monoubiquitinated Protein Deubiquitination DNA Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Abiotic Stimulus
Tagcloud ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants	20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated
Tagcloud (Difference) ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants	20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated
Tagcloud (Intersection) ?