USP28 and USP14

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		USP28	USP14
Description		ubiquitin specific peptidase 28	ubiquitin specific peptidase 14
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex	Proteasome Complex Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Synapse Extracellular Exosome Glutamatergic Synapse Presynaptic Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Proteasome Binding Deubiquitinase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Proteolysis DNA Damage Response Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Immune System Process Proteolysis Inflammatory Response Chemical Synaptic Transmission Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Ub-specific processing proteases	Ub-specific processing proteases Regulation of NF-kappa B signaling
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		43 interacting genes: ATXN3L BAP1 CDC73 CFTR CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 TTC3 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	19 interacting genes: ATF2 CDK1 CEBPA CXCR4 FANCC ISG15 OGT PSMD2 SEM1 SGTA SPAG5-AS1 TAFAZZIN TGFBR1 TRIM11 UBC USP15 USP21 USP28 XRCC6
Entrez ID		57646	9097
HPRD ID		15632	06279
Ensembl ID		ENSG00000048028	ENSG00000101557
Uniprot IDs		A0A8V8TLZ9 B4E3L3 Q96RU2	P54578
PDB IDs		2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK 7TUO 8HJE 8P14 8P19 8P1P 8P1Q	2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Post-translational Protein Modification Protein Modification Process Peptidase Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Protein K48-linked Deubiquitination Cysteine-type Endopeptidase Activity Deubiquitinase Activity Hydrolase Activity DeNEDDylase Activity Protein K63-linked Deubiquitination Ubiquitin Binding Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process P53 Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Catabolic Process Cytosol Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of TOR Signaling Protein Ubiquitination Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis DNA Repair Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin Protein Ligase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Protein Modification Process Response To Stress Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Post-translational Protein Modification Nucleus Regulation Of Multicellular Organismal Development Protein-containing Complex Protein Tag Activity Cysteine-type Deubiquitinase Activity Cellular Response To Stress DNA Damage Response White Fat Cell Differentiation DNA Damage Checkpoint Signaling Cellular Response To Chemical Stress DNA Repair Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Deubiquitinase Activity Cysteine-type Peptidase Activity Regulation Of Developmental Process Negative Regulation Of Cell Cycle Cyclin Binding Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Response To Virus DNA Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Cell Population Proliferation Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Abducens Nucleus Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
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