RIN1 and RAB5B

Number of citations of the paper that reports this interaction (PMID 11703925)
76

Data Source:
HPRD (two hybrid, in vitro)

		RIN1	RAB5B
Gene Name		Ras and Rab interactor 1	RAB5B, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dendrite Neuronal Cell Body	Intracellular Endosome Early Endosome Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Ras GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding
	Biological Process	Endocytosis Signal Transduction Memory Associative Learning Negative Regulation Of Synaptic Plasticity Positive Regulation Of GTPase Activity	Intracellular Protein Transport Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Polycystic ovary syndrome ( 22885925) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Protein-Protein Interactions		15 interactors: ABL1 ABL2 CALCOCO2 ERBB2 ERBB3 HRAS LZTS2 MLLT4 RAB5A RAB5B RALGDS RRAS2 YWHAB YWHAE YWHAZ	15 interactors: APOA5 CDK1 CHM EEA1 RAB7A RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		9610	5869
HPRD ID		05813	01544
Ensembl ID		ENSG00000174791	ENSG00000111540
Uniprot IDs		Q13671	P61020
PDB IDs			2HEI
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Signaling Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Apoptotic Signaling Pathway Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway Response To Stimulus Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Defense Response Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Catalytic Activity Immune System Process Regulation Of Cell Death Regulation Of Cellular Localization Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Interferon-gamma Secretion Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Wounding Regulation Of Catalytic Activity Axon Guidance Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Endocytosis Response To Organic Substance Negative Regulation Of Protein Dephosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Localization	Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Vesicle-mediated Transport Endocytosis Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Endosomal Transport Regulation Of Ras GTPase Activity Organelle Fusion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Transport Early Endosome To Late Endosome Transport Membrane Organization Regulation Of Signaling Cellular Localization Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Vesicle Fusion Protein Localization Regulation Of Signal Transduction Establishment Of Localization In Cell Synaptic Vesicle To Endosome Fusion Pronuclear Fusion Epidermal Growth Factor Catabolic Process Retrograde Transport, Endosome To Golgi Nuclear Envelope Organization Organ Regeneration Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Intracellular Transport Nuclear Matrix Organization Negative Regulation Of Synaptic Plasticity Nuclear Matrix Anchoring At Nuclear Membrane Nucleus Organization Phagosome-lysosome Fusion Nuclear Migration Along Microfilament Regulation Of Metabolic Process Membrane Fusion Phagosome Acidification Protein Localization To Organelle Regulation Of Schwann Cell Differentiation Protein Geranylgeranylation Protein To Membrane Docking
Tagcloud ?		abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks rbm10 responder responders seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Difference) ?		abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks rbm10 responder responders seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Intersection) ?