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PRKAG1 and PRKAB2
Number of citations of the paper that reports this interaction (PMID
10698692
)
99
Data Source:
HPRD
(two hybrid)
PRKAG1
PRKAB2
Gene Name
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Membrane
AMP-activated Protein Kinase Complex
Extracellular Vesicular Exosome
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Molecular Function
Protein Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
CAMP-dependent Protein Kinase Regulator Activity
AMP Binding
Protein Kinase Binding
ADP Binding
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
Regulation Of Glycolytic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Spermatogenesis
Insulin Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Protein Kinase Activity
Protein Heterooligomerization
Membrane Organization
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Pathways
Organelle biogenesis and maintenance
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-mediated signalling
Regulation of Rheb GTPase activity by AMPK
mTOR signalling
Translocation of GLUT4 to the plasma membrane
IRS-related events
mTOR signalling
IGF1R signaling cascade
Mitochondrial biogenesis
IRS-related events triggered by IGF1R
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Adenosine monophosphate
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
ACACA
AP1S3
C1orf94
CBS
KCNN4
KEAP1
KRTAP10-3
KRTAP4-2
PAICS
PRKAA1
PRKAA2
PRKAB1
PRKAB2
PRKAG2
TEKT1
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
Entrez ID
5571
5565
HPRD ID
04118
04117
Ensembl ID
ENSG00000181929
ENSG00000131791
Uniprot IDs
F8W9D1
P54619
O43741
PDB IDs
2UV4
2UV5
2UV6
2UV7
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
Enriched GO Terms of Interacting Partners
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Carnitine Shuttle
Carnitine Transmembrane Transport
Carnitine Transport
Fatty Acid Biosynthetic Process
Quaternary Ammonium Group Transport
Long-chain Fatty Acid Transport
Fatty Acid Metabolic Process
Ammonium Transmembrane Transport
Cell Cycle Arrest
Insulin Receptor Signaling Pathway
Fatty Acid Transport
Ammonium Transport
Cellular Response To Insulin Stimulus
Lipid Biosynthetic Process
Monocarboxylic Acid Metabolic Process
Carboxylic Acid Metabolic Process
Response To Insulin
Lipid Transport
Cellular Response To Peptide Hormone Stimulus
Organic Acid Metabolic Process
Regulation Of Glycolytic Process
Lipid Localization
Cellular Response To Peptide
Monocarboxylic Acid Transport
Regulation Of Lipid Biosynthetic Process
Energy Reserve Metabolic Process
Regulation Of Fatty Acid Biosynthetic Process
Mitochondrial Transport
Membrane Organization
Organic Anion Transport
Sterol Biosynthetic Process
Negative Regulation Of Cell Cycle
Response To Peptide Hormone
Small Molecule Metabolic Process
Cellular Response To Organonitrogen Compound
Response To Peptide
Cellular Lipid Metabolic Process
Cellular Response To Hormone Stimulus
Inorganic Anion Transport
Regulation Of Generation Of Precursor Metabolites And Energy
Monovalent Inorganic Cation Transport
Anion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Fatty Acid Metabolic Process
Regulation Of Lipid Metabolic Process
Energy Derivation By Oxidation Of Organic Compounds
Carboxylic Acid Transport
Organic Acid Transport
Lipid Metabolic Process
Regulation Of Energy Homeostasis
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
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