PRKAG1 and ACACA

Number of citations of the paper that reports this interaction (PMID 18480843)
26

Data Source:
BioGRID (enzymatic study)

		PRKAG1	ACACA
Gene Name		protein kinase, AMP-activated, gamma 1 non-catalytic subunit	acetyl-CoA carboxylase alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome	Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Binding ADP Binding	Acetyl-CoA Carboxylase Activity Biotin Carboxylase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Spermatogenesis Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization	Tissue Homeostasis Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Carnitine Shuttle Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Multicellular Organismal Protein Metabolic Process Small Molecule Metabolic Process Protein Homotetramerization Lipid Homeostasis Malonyl-CoA Biosynthetic Process
Pathways		Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Import of palmitoyl-CoA into the mitochondrial matrix Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Fatty Acyl-CoA Biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Triglyceride Biosynthesis Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism
Drugs			Biotin
Diseases
GWAS			Ovarian cancer ( 23535730)
Protein-Protein Interactions		15 interactors: ACACA AP1S3 C1orf94 CBS KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1	9 interactors: ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 PRKAA1 PRKAA2 PRKAB1 PRKAG1
Entrez ID		5571	31
HPRD ID		04118	01938
Ensembl ID		ENSG00000181929	ENSG00000132142
Uniprot IDs		F8W9D1 P54619	B2ZZ90 Q13085 Q7Z5W8
PDB IDs		2UV4 2UV5 2UV6 2UV7	2YL2 3COJ 4ASI
Enriched GO Terms of Interacting Partners?		Carnitine Shuttle Carnitine Transmembrane Transport Carnitine Transport Fatty Acid Biosynthetic Process Quaternary Ammonium Group Transport Long-chain Fatty Acid Transport Fatty Acid Metabolic Process Ammonium Transmembrane Transport Cell Cycle Arrest Insulin Receptor Signaling Pathway Fatty Acid Transport Ammonium Transport Cellular Response To Insulin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Response To Insulin Lipid Transport Cellular Response To Peptide Hormone Stimulus Organic Acid Metabolic Process Regulation Of Glycolytic Process Lipid Localization Cellular Response To Peptide Monocarboxylic Acid Transport Regulation Of Lipid Biosynthetic Process Energy Reserve Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Mitochondrial Transport Membrane Organization Organic Anion Transport Sterol Biosynthetic Process Negative Regulation Of Cell Cycle Response To Peptide Hormone Small Molecule Metabolic Process Cellular Response To Organonitrogen Compound Response To Peptide Cellular Lipid Metabolic Process Cellular Response To Hormone Stimulus Inorganic Anion Transport Regulation Of Generation Of Precursor Metabolites And Energy Monovalent Inorganic Cation Transport Anion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Organic Acid Transport Lipid Metabolic Process Regulation Of Energy Homeostasis	Negative Regulation Of Cell Cycle Fatty Acid Biosynthetic Process Regulation Of Cell Cycle Cell Cycle Process Cell Cycle Fatty Acid Metabolic Process Regulation Of Glycolytic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Protein Phosphorylation Wnt Signaling Pathway Response To Insulin Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Chromosome Organization Response To Organonitrogen Compound Biosynthetic Process Regulation Of Gene Expression Response To Hormone Cellular Lipid Metabolic Process Phosphorylation Cellular Protein Modification Process Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process Carboxylic Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Peptide Hormone Fatty Acid Homeostasis Protein Heterooligomerization Positive Regulation Of Metabolic Process Regulation Of Lipid Biosynthetic Process Signaling Response To Peptide Cell Communication Organic Acid Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Lipid Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Glucose Starvation Regulation Of Chromosome Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Checkpoint
Tagcloud ?			aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg
Tagcloud (Difference) ?			aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg
Tagcloud (Intersection) ?