PRKAG1 and ACACA

Number of citations of the paper that reports this interaction (PubMedID 18480843)
49

Data Source:
BioGRID (enzymatic study)

		PRKAG1	ACACA
Description		protein kinase AMP-activated non-catalytic subunit gamma 1	acetyl-CoA carboxylase alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex	Fibrillar Center Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton
	Molecular Function	Nucleotide Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding Protein-containing Complex Binding	Nucleotide Binding Catalytic Activity Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Spermatogenesis Cellular Response To Nutrient Levels Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Positive Regulation Of Gluconeogenesis Import Into Nucleus Regulation Of Cell Cycle	Tissue Homeostasis Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib	Biotin
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)	Daytime nap ( 33568662) Ovarian cancer ( 23535730)
Interacting Genes		31 interacting genes: ACACA AP1S3 C1orf94 CBS CRBN EIF3G KCNN4 KEAP1 KLHL20 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 PRKDC TEKT1 TNFAIP1	15 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 NEIL3 PRKAA1 PRKAA2 PRKAB1 PRKAG1 TRIB1 TRIB2 TRIB3
Entrez ID		5571	31
HPRD ID		04118	01938
Ensembl ID		ENSG00000181929	ENSG00000278540
Uniprot IDs		F8VYY9 P54619	Q13085 Q7Z5W8
PDB IDs		2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74 7MYJ 8BIK	2YL2 3COJ 4ASI 6G2D 6G2H 6G2I 8XKZ 8XL0 8XL1 8XL2
Enriched GO Terms of Interacting Partners?		Keratin Filament Nucleotide-activated Protein Kinase Complex Intermediate Filament AMP-activated Protein Kinase Activity Carboxylic Acid Biosynthetic Process Cytosol Fatty Acid Biosynthetic Process Small Molecule Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Fatty Acid Metabolic Process Response To Prostaglandin E Protein Localization To Lipid Droplet Monocarboxylic Acid Metabolic Process Somite Specification Carboxylic Acid Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Organic Acid Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Sterol Biosynthetic Process Cellular Response To Glucose Starvation Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Phosphatidylethanolamine Biosynthetic Process Cul3-RING Ubiquitin Ligase Complex Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Homotetramerization HMG Box Domain Binding Regulation Of Carbohydrate Catabolic Process Response To Nutrient Levels L-serine Metabolic Process Hair Cycle Segment Specification Somite Development Regulation Of ATP Metabolic Process Lipid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Protein Homooligomerization Regulation Of Purine Nucleotide Metabolic Process Steroid Biosynthetic Process Protein Tetramerization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylcholine Biosynthetic Process	Nucleotide-activated Protein Kinase Complex Ubiquitin-protein Transferase Regulator Activity AMP-activated Protein Kinase Activity Fatty Acid Biosynthetic Process Mitogen-activated Protein Kinase Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Small Molecule Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Phosphorus Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Lipid Metabolic Process Carboxylic Acid Biosynthetic Process Protein Kinase CK2 Complex Protein Kinase Activity Protein Localization To Lipid Droplet Fatty Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Catabolic Process Protein Kinase Inhibitor Activity Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Tubulin Deacetylation CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Cellular Response To Glucose Starvation Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Tubulin Deacetylation Regulation Of Glycolytic Process Lipid Droplet Disassembly Regulation Of Proteolysis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Lipid Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MAP Kinase Activity Cellular Response To Stress Negative Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Phosphatidylethanolamine Biosynthetic Process Small Molecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Protein Deacetylation
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