PRKAG1 and PRKAG2

Number of citations of the paper that reports this interaction (PMID 10698692)
99

Data Source:
HPRD (two hybrid)

		PRKAG1	PRKAG2
Gene Name		protein kinase, AMP-activated, gamma 1 non-catalytic subunit	protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome	Extracellular Space Nucleoplasm Cytosol AMP-activated Protein Kinase Complex
	Molecular Function	Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Binding ADP Binding	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Spermatogenesis Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization	Glycogen Metabolic Process Regulation Of Glycolytic Process Energy Reserve Metabolic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Membrane Organization Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Bipolar disorder (age of onset and psychomotor symptoms) ( 21305692) Chronic kidney disease ( 20383146) Hematocrit ( 19862010) Hemoglobin ( 19862010) Red blood cell traits ( 23222517) Urate levels ( 23263486)
Protein-Protein Interactions		15 interactors: ACACA AP1S3 C1orf94 CBS KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1	3 interactors: PRKAB1 PRKAB2 PRKAG1
Entrez ID		5571	51422
HPRD ID		04118	04119
Ensembl ID		ENSG00000181929	ENSG00000106617
Uniprot IDs		F8W9D1 P54619	G8JLM0 Q9UGJ0
PDB IDs		2UV4 2UV5 2UV6 2UV7
Enriched GO Terms of Interacting Partners?		Carnitine Shuttle Carnitine Transmembrane Transport Carnitine Transport Fatty Acid Biosynthetic Process Quaternary Ammonium Group Transport Long-chain Fatty Acid Transport Fatty Acid Metabolic Process Ammonium Transmembrane Transport Cell Cycle Arrest Insulin Receptor Signaling Pathway Fatty Acid Transport Ammonium Transport Cellular Response To Insulin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Response To Insulin Lipid Transport Cellular Response To Peptide Hormone Stimulus Organic Acid Metabolic Process Regulation Of Glycolytic Process Lipid Localization Cellular Response To Peptide Monocarboxylic Acid Transport Regulation Of Lipid Biosynthetic Process Energy Reserve Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Mitochondrial Transport Membrane Organization Organic Anion Transport Sterol Biosynthetic Process Negative Regulation Of Cell Cycle Response To Peptide Hormone Small Molecule Metabolic Process Cellular Response To Organonitrogen Compound Response To Peptide Cellular Lipid Metabolic Process Cellular Response To Hormone Stimulus Inorganic Anion Transport Regulation Of Generation Of Precursor Metabolites And Energy Monovalent Inorganic Cation Transport Anion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Organic Acid Transport Lipid Metabolic Process Regulation Of Energy Homeostasis	Fatty Acid Biosynthetic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Fatty Acid Metabolic Process Cellular Response To Peptide Mitochondrion Organization Negative Regulation Of Cell Cycle Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Membrane Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cell Cycle Process Protein Heterooligomerization Regulation Of Protein Phosphorylation Organic Acid Metabolic Process Lipid Metabolic Process Regulation Of Phosphorylation Protein Phosphorylation Cell Cycle Regulation Of Phosphorus Metabolic Process Phosphorylation Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein Oligomerization Small Molecule Metabolic Process Carnitine Shuttle Regulation Of Catalytic Activity Response To Organic Substance Carnitine Transmembrane Transport Carnitine Transport Phosphate-containing Compound Metabolic Process Quaternary Ammonium Group Transport Cell Surface Receptor Signaling Pathway Organelle Organization
Tagcloud ?			aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Difference) ?			aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Intersection) ?