PRKAG1 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRKAG1	PLEKHF2
Description		protein kinase AMP-activated non-catalytic subunit gamma 1	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Nucleotide Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding Protein-containing Complex Binding	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Spermatogenesis Cellular Response To Nutrient Levels Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Positive Regulation Of Gluconeogenesis Import Into Nucleus Regulation Of Cell Cycle	Endosome Organization Endosome To Lysosome Transport Protein Transport
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)	Radiation response ( 20923822)
Interacting Genes		31 interacting genes: ACACA AP1S3 C1orf94 CBS CRBN EIF3G KCNN4 KEAP1 KLHL20 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 PRKDC TEKT1 TNFAIP1	168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		5571	79666
HPRD ID		04118	15147
Ensembl ID		ENSG00000181929	ENSG00000175895
Uniprot IDs		F8VYY9 P54619	Q9H8W4
PDB IDs		2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Keratin Filament Nucleotide-activated Protein Kinase Complex Intermediate Filament AMP-activated Protein Kinase Activity Carboxylic Acid Biosynthetic Process Cytosol Fatty Acid Biosynthetic Process Small Molecule Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Fatty Acid Metabolic Process Response To Prostaglandin E Protein Localization To Lipid Droplet Monocarboxylic Acid Metabolic Process Somite Specification Carboxylic Acid Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Organic Acid Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Sterol Biosynthetic Process Cellular Response To Glucose Starvation Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Phosphatidylethanolamine Biosynthetic Process Cul3-RING Ubiquitin Ligase Complex Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Homotetramerization HMG Box Domain Binding Regulation Of Carbohydrate Catabolic Process Response To Nutrient Levels L-serine Metabolic Process Hair Cycle Segment Specification Somite Development Regulation Of ATP Metabolic Process Lipid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Protein Homooligomerization Regulation Of Purine Nucleotide Metabolic Process Steroid Biosynthetic Process Protein Tetramerization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylcholine Biosynthetic Process	Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation
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