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PRKAG1 and KCNN4
Number of citations of the paper that reports this interaction (PMID
19052260
)
13
Data Source:
HPRD
(in vivo, two hybrid)
PRKAG1
KCNN4
Gene Name
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Membrane
AMP-activated Protein Kinase Complex
Extracellular Vesicular Exosome
Plasma Membrane
Voltage-gated Potassium Channel Complex
Basolateral Plasma Membrane
Apical Plasma Membrane
Neuronal Cell Body
Membrane Raft
Molecular Function
Protein Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
CAMP-dependent Protein Kinase Regulator Activity
AMP Binding
Protein Kinase Binding
ADP Binding
Protein Binding
Calmodulin Binding
Calcium-activated Potassium Channel Activity
Small Conductance Calcium-activated Potassium Channel Activity
Protein Phosphatase Binding
Intermediate Conductance Calcium-activated Potassium Channel Activity
Biological Process
Regulation Of Glycolytic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Spermatogenesis
Insulin Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Protein Kinase Activity
Protein Heterooligomerization
Membrane Organization
Immune System Process
Potassium Ion Transport
Calcium Ion Transport
Cell Volume Homeostasis
Defense Response
Synaptic Transmission
Stabilization Of Membrane Potential
Phospholipid Translocation
Saliva Secretion
Positive Regulation Of Protein Secretion
Positive Regulation Of T Cell Receptor Signaling Pathway
Potassium Ion Export
Potassium Ion Transmembrane Transport
Pathways
Organelle biogenesis and maintenance
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-mediated signalling
Regulation of Rheb GTPase activity by AMPK
mTOR signalling
Translocation of GLUT4 to the plasma membrane
IRS-related events
mTOR signalling
IGF1R signaling cascade
Mitochondrial biogenesis
IRS-related events triggered by IGF1R
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Ca2+ activated K+ channels
Potassium Channels
Drugs
Clotrimazole
Quinine
Miconazole
Halothane
Diseases
GWAS
Breast cancer (
23535729
)
Protein-Protein Interactions
15 interactors:
ACACA
AP1S3
C1orf94
CBS
KCNN4
KEAP1
KRTAP10-3
KRTAP4-2
PAICS
PRKAA1
PRKAA2
PRKAB1
PRKAB2
PRKAG2
TEKT1
2 interactors:
CALM1
PRKAG1
Entrez ID
5571
3783
HPRD ID
04118
04130
Ensembl ID
ENSG00000181929
ENSG00000104783
Uniprot IDs
F8W9D1
P54619
D1MQ08
D1MQ09
O15554
PDB IDs
2UV4
2UV5
2UV6
2UV7
Enriched GO Terms of Interacting Partners
?
Carnitine Shuttle
Carnitine Transmembrane Transport
Carnitine Transport
Fatty Acid Biosynthetic Process
Quaternary Ammonium Group Transport
Long-chain Fatty Acid Transport
Fatty Acid Metabolic Process
Ammonium Transmembrane Transport
Cell Cycle Arrest
Insulin Receptor Signaling Pathway
Fatty Acid Transport
Ammonium Transport
Cellular Response To Insulin Stimulus
Lipid Biosynthetic Process
Monocarboxylic Acid Metabolic Process
Carboxylic Acid Metabolic Process
Response To Insulin
Lipid Transport
Cellular Response To Peptide Hormone Stimulus
Organic Acid Metabolic Process
Regulation Of Glycolytic Process
Lipid Localization
Cellular Response To Peptide
Monocarboxylic Acid Transport
Regulation Of Lipid Biosynthetic Process
Energy Reserve Metabolic Process
Regulation Of Fatty Acid Biosynthetic Process
Mitochondrial Transport
Membrane Organization
Organic Anion Transport
Sterol Biosynthetic Process
Negative Regulation Of Cell Cycle
Response To Peptide Hormone
Small Molecule Metabolic Process
Cellular Response To Organonitrogen Compound
Response To Peptide
Cellular Lipid Metabolic Process
Cellular Response To Hormone Stimulus
Inorganic Anion Transport
Regulation Of Generation Of Precursor Metabolites And Energy
Monovalent Inorganic Cation Transport
Anion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Fatty Acid Metabolic Process
Regulation Of Lipid Metabolic Process
Energy Derivation By Oxidation Of Organic Compounds
Carboxylic Acid Transport
Organic Acid Transport
Lipid Metabolic Process
Regulation Of Energy Homeostasis
Mitochondrion Organization
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Regulation Of High Voltage-gated Calcium Channel Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Positive Regulation Of Transferase Activity
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Detection Of Calcium Ion
Regulation Of Protein Kinase Activity
Regulation Of Cell Communication By Electrical Coupling
Positive Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Kinase Activity
Response To Organonitrogen Compound
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Protein Autophosphorylation
Membrane Organization
Positive Regulation Of Phosphorylation
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Glycogen Catabolic Process
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Cell Cycle
Regulation Of Voltage-gated Calcium Channel Activity
Response To Hormone
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Cation Channel Activity
Polysaccharide Catabolic Process
Positive Regulation Of Monooxygenase Activity
Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
Positive Regulation Of Calcium Ion Transmembrane Transporter Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Protein Phosphorylation
Regulation Of Rhodopsin Mediated Signaling Pathway
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Glycolytic Process
Activation Of Adenylate Cyclase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Nitric Oxide Metabolic Process
Regulation Of Protein Autophosphorylation
Reactive Nitrogen Species Metabolic Process
Rhodopsin Mediated Signaling Pathway
Cellular Carbohydrate Catabolic Process
Positive Regulation Of Phosphatase Activity
Tagcloud
?
blockers
blocking
cns
contributes
contributions
counteract
damaged
ganglion
greatly
highlights
ik1
instance
jak3
kca3
mek
microglia
microglial
migratory
neurotoxicity
optic
p2y2
phosphatidylinositol
pursuing
rescued
rodent
sk4
stat6
surprisingly
tram
Tagcloud (Difference)
?
blockers
blocking
cns
contributes
contributions
counteract
damaged
ganglion
greatly
highlights
ik1
instance
jak3
kca3
mek
microglia
microglial
migratory
neurotoxicity
optic
p2y2
phosphatidylinositol
pursuing
rescued
rodent
sk4
stat6
surprisingly
tram
Tagcloud (Intersection)
?