VAC14 and CASP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VAC14	CASP1
Gene Name		Vac14 homolog (S. cerevisiae)	caspase 1, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endosome Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex	Extracellular Region Cytoplasm Cytosol IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Receptor Activity Protein Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Regulation Of Lipid Kinase Activity Small Molecule Metabolic Process	Response To Hypoxia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Autophagy Response To Lipopolysaccharide Interleukin-1 Beta Production Response To ATP Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Mitochondrial Depolarization Membrane Hyperpolarization Pyroptosis Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Execution Phase Of Apoptosis Programmed Necrotic Cell Death Toxin Transport
Pathways		Phospholipid metabolism Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the late endosome membrane Metabolism Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the early endosome membrane PI Metabolism Phospholipid metabolism PI Metabolism	Signaling by Interleukins The NLRP3 inflammasome Inflammasomes NOD1/2 Signaling Pathway The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Interleukin-1 processing The IPAF inflammasome Cytokine Signaling in Immune system Innate Immune System
Drugs			Minocycline 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ACSS1 APP ASB13 BHLHE40 C11orf54 C4orf33 CASP1 CCBL1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 DDAH2 FIG4 FNDC3B JMJD7 KRTAP19-5 KRTAP19-7 LINC00518 LPAL2 MGAT5B MPPED2 MTMR9 MVP NGB NOS1 PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PRADC1 PRR13 PRR20A RBFOX2 RHOXF2 SIGLEC5 SMUG1 SNF8 SPRYD7 TCEANC TP53BP1 WDYHV1 ZNF34	42 interactors: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17 CARD8 CASP10 CASP14 CASP4 CASP8 CAST CDK11B EGFR FGF2 HTT IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARK2 PARP1 PLA2G4A PLA2G4B PSEN1 PSEN2 PYCARD RIPK2 TFAP2A TIRAP VAC14
Entrez ID		55697	834
HPRD ID		07660	00977
Ensembl ID		ENSG00000103043	ENSG00000137752
Uniprot IDs		Q08AM6 Q9NTB8	A8K249 A8K257 P29466
PDB IDs			1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7
Enriched GO Terms of Interacting Partners?		Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Arginine Metabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Nitric Oxide Metabolic Process Cellular Amino Acid Catabolic Process Cell Recognition Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Neuron Maturation Myelin Assembly Second-messenger-mediated Signaling Myelination Neuron Recognition Axon Ensheathment	Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Response To Stress Immune Response Signaling Regulation Of Signaling Cell Communication Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Proteolysis Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Cell Death Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Localization Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Immune System Process Signal Transduction Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Protein Processing Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Positive Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi pikfyve spontaneous summarizes tooth turnover utility varon yunis	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi pikfyve spontaneous summarizes tooth turnover utility varon yunis	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?