CASP1 and IL1A

Number of citations of the paper that reports this interaction (PubMedID 18329368)
0

Data Source:
HPRD (in vivo)

		CASP1	IL1A
Description		caspase 1	interleukin 1 alpha
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Intracellular Sodium Ion Homeostasis Apoptotic Process Response To Stress Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cell Division Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses	Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs		Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID	Rilonacept
Diseases			Graft-versus-host disease
GWAS		Hip circumference adjusted for BMI ( 28552196)	Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		834	3552
HPRD ID		00977	00988
Ensembl ID		ENSG00000137752	ENSG00000115008
Uniprot IDs		A8K249 A8K257 P29466	P01583
PDB IDs		1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA	2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction	Interleukin-1 Binding Interleukin-1 Receptor Activity Interleukin-1-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Response To Cytokine Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Interleukin-1, Type I, Activating Receptor Activity Interleukin-33 Receptor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Alpha Production Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin AIM2 Inflammasome Complex IPAF Inflammasome Complex Calpain Complex Viral Penetration Into Host Nucleus Mammary Gland Involution Cysteine-type Peptidase Activity Cytokine Precursor Processing Positive Regulation Of Neutrophil Extravasation Somite Specification Granulocyte Colony-stimulating Factor Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Peptide
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