VAC14 and TP53BP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VAC14	TP53BP1
Gene Name		Vac14 homolog (S. cerevisiae)	tumor protein p53 binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endosome Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm
	Molecular Function	Receptor Activity Protein Binding	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Cofactor Activity P53 Binding Damaged DNA Binding Protein Binding Methylated Histone Binding Telomeric DNA Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Regulation Of Lipid Kinase Activity Small Molecule Metabolic Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Phospholipid metabolism Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the late endosome membrane Metabolism Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the early endosome membrane PI Metabolism Phospholipid metabolism PI Metabolism	Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ACSS1 APP ASB13 BHLHE40 C11orf54 C4orf33 CASP1 CCBL1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 DDAH2 FIG4 FNDC3B JMJD7 KRTAP19-5 KRTAP19-7 LINC00518 LPAL2 MGAT5B MPPED2 MTMR9 MVP NGB NOS1 PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PRADC1 PRR13 PRR20A RBFOX2 RHOXF2 SIGLEC5 SMUG1 SNF8 SPRYD7 TCEANC TP53BP1 WDYHV1 ZNF34	34 interactors: ARAP1 ATM BLM BRCA1 CCNB1 CDK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AFX HIST1H4A HIST2H4A HIST4H4 IFI16 LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 PAXIP1 PCNT PLK1 RAD18 RELA SPAG9 TFDP1 TP53 USP28 VAC14
Entrez ID		55697	7158
HPRD ID		07660	05569
Ensembl ID		ENSG00000103043	ENSG00000067369
Uniprot IDs		Q08AM6 Q9NTB8	F8VY86 Q12888
PDB IDs			1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0
Enriched GO Terms of Interacting Partners?		Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Arginine Metabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Nitric Oxide Metabolic Process Cellular Amino Acid Catabolic Process Cell Recognition Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Neuron Maturation Myelin Assembly Second-messenger-mediated Signaling Myelination Neuron Recognition Axon Ensheathment	Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Process DNA Damage Checkpoint DNA Metabolic Process Response To Abiotic Stimulus Response To Radiation Mitotic Cell Cycle Process Cell Cycle Checkpoint DNA Repair Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Response To Stress Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cell Death Telomere Maintenance Death Apoptotic Signaling Pathway DNA Recombination Intracellular Signal Transduction Regulation Of Metabolic Process G2 DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Phase Transition Histone Modification Cell Cycle Phase Transition Apoptotic Process DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Programmed Cell Death DNA Packaging Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi pikfyve spontaneous summarizes tooth turnover utility varon yunis	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Difference) ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi pikfyve spontaneous summarizes tooth turnover utility varon yunis	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Intersection) ?