CASP1 and GSDMD

Number of citations of the paper that reports this interaction (PubMedID 34296442)
50

Data Source:
BioGRID (pull down)

		CASP1	GSDMD
Description		caspase 1	gasdermin D
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Lumen Canonical Inflammasome Complex NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Plasma Membrane Repair Immune System Process Inflammatory Response Protein Secretion Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Ceramide Biosynthetic Process Pore Complex Assembly Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Transmembrane Transport Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Pyroptotic Cell Death
Pathways		NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses	Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs		Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196)	Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14	9 interacting genes: ASPG CASP1 KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558
Entrez ID		834	79792
HPRD ID		00977	11014
Ensembl ID		ENSG00000137752	ENSG00000104518
Uniprot IDs		A8K249 A8K257 P29466	P57764
PDB IDs		1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA	5NH1 5WQT 6AO4 6KN0 6N9O 6VFE 7Z1X
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction
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