VAC14 and WRAP53

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAC14	WRAP53
Description		VAC14 component of PIKFYVE complex	WD repeat containing antisense to TP53
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GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Cytosol Cajal Body Nuclear Body Site Of Double-strand Break
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Telomerase RNA Binding Protein Carrier Chaperone RNA Folding Chaperone
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	DNA Repair DNA Damage Response Telomere Maintenance Via Telomerase Cajal Body Organization Telomere Formation Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase RNA Folding Positive Regulation Of DNA Repair ScaRNA Localization To Cajal Body Telomerase RNA Localization To Cajal Body Positive Regulation Of Establishment Of Protein Localization To Telomere Protein Localization To Cajal Body Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	Telomere Extension By Telomerase Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)	Alcohol consumption ( 31358974) Cognitive function ( 28093568)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	4 interacting genes: DSCR9 RECQL4 UBAP2 VAC14
Entrez ID		55697	55135
HPRD ID		07660	07670
Ensembl ID		ENSG00000103043	ENSG00000141499
Uniprot IDs		Q08AM6	Q9BUR4
PDB IDs		7K1Y	7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	Telomeric D-loop Binding Catalytic Activity, Acting On DNA Four-way Junction Helicase Activity Telomeric D-loop Disassembly Bubble DNA Binding DNA/DNA Annealing Activity Oxidized Purine DNA Binding PAS Complex Presynaptic Endosome Telomeric Loop Disassembly 3'-5' DNA Helicase Activity
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