VAC14 and DDAH2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VAC14	DDAH2
Gene Name		Vac14 homolog (S. cerevisiae)	dimethylarginine dimethylaminohydrolase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endosome Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex	Cytoplasm Mitochondrion Centrosome Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Protein Binding	Catalytic Activity Protein Binding Dimethylargininase Activity Amino Acid Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Regulation Of Lipid Kinase Activity Small Molecule Metabolic Process	Citrulline Metabolic Process Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process
Pathways		Phospholipid metabolism Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the late endosome membrane Metabolism Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the early endosome membrane PI Metabolism Phospholipid metabolism PI Metabolism
Drugs			L-Citrulline
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ACSS1 APP ASB13 BHLHE40 C11orf54 C4orf33 CASP1 CCBL1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 DDAH2 FIG4 FNDC3B JMJD7 KRTAP19-5 KRTAP19-7 LINC00518 LPAL2 MGAT5B MPPED2 MTMR9 MVP NGB NOS1 PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PRADC1 PRR13 PRR20A RBFOX2 RHOXF2 SIGLEC5 SMUG1 SNF8 SPRYD7 TCEANC TP53BP1 WDYHV1 ZNF34	22 interactors: ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 GADD45G MKNK1 PIN1 RAP1B RCC1 RPS6KA1 RPS6KA5 SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14 ZAK
Entrez ID		55697	23564
HPRD ID		07660	09204
Ensembl ID		ENSG00000103043	ENSG00000213722
Uniprot IDs		Q08AM6 Q9NTB8	O95865
PDB IDs
Enriched GO Terms of Interacting Partners?		Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Arginine Metabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Nitric Oxide Metabolic Process Cellular Amino Acid Catabolic Process Cell Recognition Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Neuron Maturation Myelin Assembly Second-messenger-mediated Signaling Myelination Neuron Recognition Axon Ensheathment	Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Response To Stress Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Posttranscriptional Regulation Of Gene Expression Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Signal Transduction By Phosphorylation Response To Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of JNK Cascade Cell Cycle Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Stress-activated MAPK Cascade Signal Transduction Regulation Of Mitotic Cell Cycle Cellular Response To Stress Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway MAPK Cascade Developmental Process Regulation Of Cellular Process Regulation Of Cell Cycle Process Signaling
Tagcloud ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi pikfyve spontaneous summarizes tooth turnover utility varon yunis	adjustment adma anova arthritis asymmetric cv ddah1 dimethylaminohydrolase dimethylarginine erythrocyte esr genotyped give homa homeostatic initially lightcycler multivariate namely polymorphisms ra relate rheumatoid sedimentation snps tag traditional variables
Tagcloud (Difference) ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi pikfyve spontaneous summarizes tooth turnover utility varon yunis	adjustment adma anova arthritis asymmetric cv ddah1 dimethylaminohydrolase dimethylarginine erythrocyte esr genotyped give homa homeostatic initially lightcycler multivariate namely polymorphisms ra relate rheumatoid sedimentation snps tag traditional variables
Tagcloud (Intersection) ?