CASP1 and NLRC4

Number of citations of the paper that reports this interaction (PubMedID 11472070)
0

Data Source:
HPRD (in vitro, in vivo)

		CASP1	NLRC4
Description		caspase 1	NLR family CARD domain containing 4
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex	Cytoplasm Cytosol Plasma Membrane Canonical Inflammasome Complex IPAF Inflammasome Complex
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Endopeptidase Activator Activity Caspase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Positive Regulation Of Protein Processing Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Icosanoid Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptotic Inflammatory Response
Pathways		NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses	TP53 Regulates Transcription of Caspase Activators and Caspases The IPAF inflammasome The IPAF inflammasome
Drugs		Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196)	Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14	6 interacting genes: BCL10 CASP1 FOXP1 NLRP4 NOD2 PYCARD
Entrez ID		834	58484
HPRD ID		00977	06014
Ensembl ID		ENSG00000137752	ENSG00000091106
Uniprot IDs		A8K249 A8K257 P29466	Q9NPP4
PDB IDs		1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA	6K8J 6MKS 6N1I 8FVU 8FW2 8FW9
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction	Positive Regulation Of NF-kappaB Transcription Factor Activity CARD Domain Binding Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of DNA-binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Regulation Of Interleukin-1 Production Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response-activating Signaling Pathway AIM2 Inflammasome Complex Cellular Response To Lipopolysaccharide Positive Regulation Of Cytokine Production Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Leukocyte Apoptotic Process Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Apoptotic Process NLRP1 Inflammasome Complex Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-1 Production Protein-containing Complex Positive Regulation Of Innate Immune Response Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Immune Response-activating Signaling Pathway Positive Regulation Of Interleukin-6 Production Response To Stress Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical Inflammasome Complex Negative Regulation Of B Cell Apoptotic Process Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune System Process
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