VAC14 and PIKFYVE

Number of citations of the paper that reports this interaction (PMID 19037259)
52

Data Source:
BioGRID (two hybrid, two hybrid)

		VAC14	PIKFYVE
Gene Name		Vac14 homolog (S. cerevisiae)	phosphoinositide kinase, FYVE finger containing
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endosome Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex	Golgi Membrane Cytosol Cell-cell Junction Endosome Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Activity Protein Binding	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Regulation Of Lipid Kinase Activity Small Molecule Metabolic Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Myelin Assembly Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways		Phospholipid metabolism Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the late endosome membrane Metabolism Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the early endosome membrane PI Metabolism Phospholipid metabolism PI Metabolism	Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Phospholipid metabolism Synthesis of PIPs at the late endosome membrane PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ACSS1 APP ASB13 BHLHE40 C11orf54 C4orf33 CASP1 CCBL1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 DDAH2 FIG4 FNDC3B JMJD7 KRTAP19-5 KRTAP19-7 LINC00518 LPAL2 MGAT5B MPPED2 MTMR9 MVP NGB NOS1 PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PRADC1 PRR13 PRR20A RBFOX2 RHOXF2 SIGLEC5 SMUG1 SNF8 SPRYD7 TCEANC TP53BP1 WDYHV1 ZNF34	3 interactors: APP RABEPK VAC14
Entrez ID		55697	200576
HPRD ID		07660	17852
Ensembl ID		ENSG00000103043	ENSG00000115020
Uniprot IDs		Q08AM6 Q9NTB8	Q9Y2I7
PDB IDs
Enriched GO Terms of Interacting Partners?		Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Arginine Metabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Nitric Oxide Metabolic Process Cellular Amino Acid Catabolic Process Cell Recognition Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Neuron Maturation Myelin Assembly Second-messenger-mediated Signaling Myelination Neuron Recognition Axon Ensheathment	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Secretion By Cell
Tagcloud ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi pikfyve spontaneous summarizes tooth turnover utility varon yunis	accordingly amp ampk atpase carriers channels creatine depleted downregulates ensures exchanger gap glycogen gsk3beta gtpase junctional labels membane monocarboxylate na osmolyte profoundly pumps rab sensing stabilizes tbc1d1 tensin transporters
Tagcloud (Difference) ?		abundance alleles biosynthesis charcot conditional dependence discovery endolysosomal fab1 fig4 highlights insight knockouts learned macromolecular manipulating marie neurological p2 p2in pi spontaneous summarizes tooth turnover utility varon yunis	accordingly amp ampk atpase carriers channels creatine depleted downregulates ensures exchanger gap glycogen gsk3beta gtpase junctional labels membane monocarboxylate na osmolyte profoundly pumps rab sensing stabilizes tbc1d1 tensin transporters
Tagcloud (Intersection) ?		pikfyve