VAC14 and ZNF34

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		VAC14	ZNF34
Description		VAC14 component of PIKFYVE complex	zinc finger protein 34
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	Generic Transcription Pathway
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)	Blood metabolite levels ( 26401656) Logical memory (immediate recall) in normal cognition ( 29274321) Type 2 diabetes ( 30054458)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	44 interacting genes: ANKHD1 CYSRT1 DAZAP2 DTX2 FOXH1 GCM2 HGS HOXC8 KRTAP10-5 KRTAP26-1 KRTAP8-1 LENG8 LMO2 MAPKBP1 MKRN3 NFYC OTX1 PITX1 PITX2 PLSCR4 POU6F2 RBPMS RBPMS2 ROR2 RSPH1 RUSC1 SPAG8 TBX3 TBX6 TCF7L2 TFG TIAM1 TLE5 TLX3 TRIP13 UBAP2 VAC14 VENTX VGLL3 VPS37C WDR25 YTHDF1 ZC3H10 ZIC1
Entrez ID		55697	80778
HPRD ID		07660	11772
Ensembl ID		ENSG00000103043	ENSG00000196378
Uniprot IDs		Q08AM6	A0A0C4DG42 E9PNZ6 Q8IZ26
PDB IDs		7K1Y
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Myoblast Fate Commitment Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Embryonic Hindlimb Morphogenesis Pattern Specification Process Embryonic Morphogenesis Hindlimb Morphogenesis Cytoplasmic Stress Granule Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Inner Ear Morphogenesis DNA Binding Outflow Tract Morphogenesis Wnt Signaling Pathway Regionalization Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Embryonic Digestive Tract Morphogenesis Axis Specification Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Cell Fate Specification Positive Regulation Of Metabolic Process Embryonic Limb Morphogenesis
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