VAC14 and BKGD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAC14	BKGD
Description		VAC14 component of PIKFYVE complex	beta-keto-L-gulonate decarboxylase
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GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome	Nucleus Nucleoplasm Cytoplasm Nuclear Body Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Metal Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Regulation Of DNA Repair DNA Damage Response
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	4 interacting genes: APP SSX2IP TRIP13 VAC14
Entrez ID		55697	28970
HPRD ID		07660	17923
Ensembl ID		ENSG00000103043	ENSG00000182919
Uniprot IDs		Q08AM6	A0A024R3B0 A0A087WT99 A8K718 Q9H0W9
PDB IDs		7K1Y	1XCR
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Transport Along Microtubule Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Meiotic Recombination Checkpoint Signaling PAS Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoskeleton-dependent Intracellular Transport Developmental Maturation Early Endosome Membrane Microtubule-based Transport Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Intraciliary Transport Involved In Cilium Assembly Axon Choice Point Recognition Female Meiosis I Heparan Sulfate Binding Signaling Receptor Activator Activity Meiotic Cell Cycle Checkpoint Signaling Presynaptic Endosome Regulation Of Endocytosis Peptidase Activator Activity
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