VAC14 and PCMTD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		VAC14	PCMTD2
Description		VAC14 component of PIKFYVE complex	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome	Cytoplasm
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)	Apolipoprotein B levels ( 32203549) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Clozapine-induced cytotoxicity ( 25656473) Coffee consumption ( 31046077) Estimated glomerular filtration rate ( 31152163) LDL cholesterol levels ( 32203549)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	5 interacting genes: ACSL6 ATP13A2 PIGP TRIP13 VAC14
Entrez ID		55697	55251
HPRD ID		07660	12764
Ensembl ID		ENSG00000103043	ENSG00000203880
Uniprot IDs		Q08AM6	Q9NV79
PDB IDs		7K1Y
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	Lipid Biosynthetic Process Organophosphate Biosynthetic Process Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity PAS Complex Phosphatidylinositol Biosynthetic Process Meiotic Recombination Checkpoint Signaling Organophosphate Metabolic Process Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Late Endosome Membrane Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Cupric Ion Binding Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Phosphatidylinositol N-acetylglucosaminyltransferase Activity Phosphatidylinositol Metabolic Process Female Meiosis I Meiotic Cell Cycle Checkpoint Signaling Lipid Metabolic Process Regulation Of Chaperone-mediated Autophagy Polyamine Transmembrane Transport Glycerophospholipid Metabolic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Presynaptic Endosome Negative Regulation Of Meiotic Nuclear Division Cellular Response To Manganese Ion Arachidonate-CoA Ligase Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process ATP Hydrolysis Activity Long-chain Fatty Acid-CoA Ligase Activity Phosphate-containing Compound Metabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion ATP Binding Negative Regulation Of Meiotic Cell Cycle Female Meiotic Nuclear Division Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Exosomal Secretion Synaptonemal Complex Assembly Endoplasmic Reticulum
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