VAC14 and GALT

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		VAC14	GALT
Description		VAC14 component of PIKFYVE complex	galactose-1-phosphate uridylyltransferase
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GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome	Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	UDP-alpha-D-glucose Metabolic Process Galactose Metabolic Process Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Carbohydrate Derivative Metabolic Process
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	Defective GALT can cause GALCT Galactose catabolism
Drugs
Diseases			Galactosemia
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	6 interacting genes: GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 VAC14
Entrez ID		55697	2592
HPRD ID		07660	06106
Ensembl ID		ENSG00000103043	ENSG00000213930
Uniprot IDs		Q08AM6	A0A0S2Z3Y7 B2RAT6 P07902
PDB IDs		7K1Y	5IN3 6GQD
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	Regulation Of Receptor-mediated Endocytosis CCR7 Chemokine Receptor Binding Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Endocytosis Chemokine Receptor Binding Immunological Synapse Formation Identical Protein Binding Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Cell Maturation Eosinophil Migration Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Response To Prostaglandin E Positive Regulation Of Granulocyte Chemotaxis Cellular Response To Prostaglandin Stimulus CCR Chemokine Receptor Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Neutrophil Migration Developmental Maturation Regulation Of Neutrophil Chemotaxis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Migration T Cell Costimulation Chemokine Activity Regulation Of Granulocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Leukocyte Apoptotic Process Cell-cell Recognition Negative Regulation Of Sequestering Of Calcium Ion NADH Dehydrogenase (quinone) (non-electrogenic) Activity Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly PAS Complex Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Granulocyte Migration Establishment Of Cell Polarity Positive Regulation Of Leukocyte Chemotaxis
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