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CASP1 and FGF2
Number of citations of the paper that reports this interaction (PubMedID
18329368
)
0
Data Source:
HPRD
(in vivo)
CASP1
FGF2
Description
caspase 1
fibroblast growth factor 2
Image
GO Annotations
Cellular Component
Nucleolus
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Membrane
Protein-containing Complex
Canonical Inflammasome Complex
IPAF Inflammasome Complex
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Protease Inhibitor Complex
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Molecular Function
Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Hydrolase Activity
Enzyme Binding
Kinase Binding
Cytokine Binding
Identical Protein Binding
CARD Domain Binding
Fibroblast Growth Factor Receptor Binding
Cytokine Activity
Integrin Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemokine Binding
Chemoattractant Activity
Identical Protein Binding
Histone H3K9me2/3 Reader Activity
Receptor-receptor Interaction
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Plasma Membrane Repair
Pattern Recognition Receptor Signaling Pathway
Proteolysis
Apoptotic Process
Inflammatory Response
Signal Transduction
Osmosensory Signaling Pathway
Protein Secretion
Protein Autoprocessing
Protein Catabolic Process
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-18 Production
Interleukin-18-mediated Signaling Pathway
Defense Response To Bacterium
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Icosanoid Biosynthetic Process
Ceramide Biosynthetic Process
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Protein Maturation
Defense Response To Virus
Protein Poly-ADP-ribosylation
Pyroptotic Inflammatory Response
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Type II Interferon
Cytokine Precursor Processing
Signaling Receptor Ligand Precursor Processing
AIM2 Inflammasome Complex Assembly
Pyroptotic Cell Death
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Angiogenesis
Osteoblast Differentiation
Branching Involved In Ureteric Bud Morphogenesis
Organ Induction
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Neuroblast Proliferation
Chromatin Organization
Transcription By RNA Polymerase II
Chemotaxis
Signal Transduction
Ras Protein Signal Transduction
Nervous System Development
Neuroblast Proliferation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Embryo Development Ending In Birth Or Egg Hatching
Animal Organ Morphogenesis
Glial Cell Differentiation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Fibroblast Migration
Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
Substantia Nigra Development
Cerebellar Granule Cell Precursor Proliferation
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Neurogenesis
Cell Differentiation
Hyaluronan Catabolic Process
Lung Development
Regulation Of Cell Migration
Paracrine Signaling
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Wound Healing
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Cell Fate Specification
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Endothelial Cell Migration
Response To Ethanol
Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Retinal Cell Programmed Cell Death
Behavioral Response To Ethanol
Embryonic Morphogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To Axon Injury
Stem Cell Differentiation
Stem Cell Development
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Cell Cycle
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Corticotropin Hormone Secreting Cell Differentiation
Thyroid-stimulating Hormone-secreting Cell Differentiation
Neuroepithelial Cell Differentiation
Chondroblast Differentiation
Mammary Gland Epithelial Cell Differentiation
Angiogenesis Involved In Coronary Vascular Morphogenesis
Negative Regulation Of Wound Healing
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Mechanical Stimulus
Stem Cell Proliferation
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Lens Fiber Cell Differentiation
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Neuroepithelial Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Sprouting Angiogenesis
Response To Wortmannin
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Lymphatic Endothelial Cell Migration
Positive Regulation Of Epithelial Tube Formation
Regulation Of Morphogenesis Of An Epithelium
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of DNA Biosynthetic Process
Negative Regulation Of Stem Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Stem Cell Differentiation
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
NOD1/2 Signaling Pathway
Interleukin-1 processing
Pyroptosis
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The AIM2 inflammasome
The IPAF inflammasome
Interleukin-37 signaling
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR2 IIIa TM
Formation of intermediate mesoderm
Formation of the nephric duct
TGFBR3 regulates FGF2 signaling
Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Acetylsalicylic acid
Minocycline
Pralnacasan
LAX-101
Emricasan
VX-765
1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
Z-Val-Ala-Asp fluoromethyl ketone
3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Sucralfate
Pentosan polysulfate
Heparin
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
ABT-510
Diseases
GWAS
Hip circumference adjusted for BMI (
28552196
)
A body shape index (
34021172
)
Acne (severe) (
30542056
)
Body mass index (
25673413
)
Irritable bowel syndrome (
24797007
)
Mosquito bite size (
28199695
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Interacting Genes
46 interacting genes:
AR
ATN1
ATXN3
BCAP31
BCL2L1
BID
CARD16
CARD17P
CARD8
CASP10
CASP14
CASP8
CAST
CDK11B
CFTR
EGFR
FGF2
GSDMD
HTT
HUWE1
IL18
IL1A
IL1B
IL33
IL37
LMNA
MAPT
NEDD4
NFE2L2
NLRC4
NLRP1
NOD1
PAK1
PARP1
PLA2G4A
PLA2G4B
PRKN
PSEN1
PSEN2
PYCARD
RIPK2
RNF31
SERPINB9
TFAP2A
TIRAP
VAC14
30 interacting genes:
API5
CASP1
CD44
CEP57
CRYAB
CSNK2A1
CSNK2A2
CSNK2B
CXCL13
FGFBP1
FGFR1
FGFR3
FGFR4
FGFRL1
GPC3
GPC4
HSPG2
NRP1
PF4
PRMT1
PTX3
RPL6
RPS19
RPS6KA3
SDC1
SDC2
SDC3
SNTG1
THBS1
VTN
Entrez ID
834
2247
HPRD ID
00977
00622
Ensembl ID
ENSG00000137752
ENSG00000138685
Uniprot IDs
A8K249
A8K257
P29466
D9ZGF5
P09038
PDB IDs
1BMQ
1IBC
1ICE
1RWK
1RWM
1RWN
1RWO
1RWP
1RWV
1RWW
1RWX
1SC1
1SC3
1SC4
2FQQ
2H48
2H4W
2H4Y
2H51
2H54
2HBQ
2HBR
2HBY
2HBZ
3D6F
3D6H
3D6M
3E4C
3NS7
5FNA
5MMV
5MTK
6BZ9
6F6R
6KN0
6PZP
6VIE
7KEU
8SV1
8WRA
1BAS
1BFB
1BFC
1BFF
1BFG
1BLA
1BLD
1CVS
1EV2
1FGA
1FQ9
1II4
1IIL
2BFH
2FGF
2M49
4FGF
4OEE
4OEF
4OEG
5X1O
6L4O
8HU7
8HUE
8OM6
Enriched GO Terms of Interacting Partners
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Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Programmed Cell Death
Cell Death
Response To Stress
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Cell Communication
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
Regulation Of Interleukin-1 Beta Production
Regulation Of Multicellular Organismal Process
Regulation Of Defense Response
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Inflammatory Response
Regulation Of Interleukin-1 Production
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Apoptotic Signaling Pathway
Regulation Of Cell Communication
Regulation Of Cytokine Production
Regulation Of Immune Response
Positive Regulation Of Cytokine Production
Response To External Biotic Stimulus
Positive Regulation Of Interleukin-1 Beta Production
Apoptotic Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Programmed Cell Death
Defense Response
Positive Regulation Of Defense Response
Positive Regulation Of Interleukin-1 Production
Defense Response To Bacterium
Identical Protein Binding
Negative Regulation Of Apoptotic Signaling Pathway
Cytosol
Protein-containing Complex
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Regulation Of Innate Immune Response
Response To Lipid
Regulation Of Immune System Process
Canonical Inflammasome Complex
Intracellular Signal Transduction
Fibroblast Growth Factor Binding
Cell Surface Receptor Signaling Pathway
Heparin Binding
Golgi Lumen
Fibroblast Growth Factor Receptor Activity
Cell Migration
Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Motility
Extracellular Region
Protein Kinase CK2 Complex
Cell Surface
Lysosomal Lumen
Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Identical Protein Binding
Negative Regulation Of Proteolysis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Endothelial Cell Migration
Regulation Of Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Cellular Response To Growth Factor Stimulus
Collagen V Binding
Positive Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Proteolysis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Apoptotic Signaling Pathway
Regulation Of Endothelial Cell Proliferation
Symbiont-mediated Disruption Of Host Cell PML Body
Developmental Process
Wnt Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Signaling
Extracellular Matrix
Regulation Of Cell Communication
Regulation Of Growth
PcG Protein Complex
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Phospholipase Activity
Positive Regulation Of MAPK Cascade
Cell Communication
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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