CASP1 and SERPINB9

Number of citations of the paper that reports this interaction (PubMedID 10477277)
50

Data Source:
BioGRID (pull down)

		CASP1	SERPINB9
Description		caspase 1	serpin family B member 9
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Mast Cell Mediated Immunity Immune Response Negative Regulation Of Endopeptidase Activity Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Process Cellular Response To Estrogen Stimulus
Pathways		NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs		Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID	Raloxifene
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196)	Left ventricular global circumferential strain ( 33495596) Plateletcrit ( 32888494) Vitiligo ( 27723757)
Interacting Genes		46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14	28 interacting genes: BRD7 CASP1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 ERG28 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1
Entrez ID		834	5272
HPRD ID		00977	03480
Ensembl ID		ENSG00000137752	ENSG00000170542
Uniprot IDs		A8K249 A8K257 P29466	A0A024QZT4 P50453
PDB IDs		1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA	8ZCR
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction	Pyroptotic Cell Death NLRP1 Inflammasome Complex Pyroptotic Inflammatory Response Nuclear Matrix Canonical Inflammasome Complex Response To Osmotic Stress Interleukin-18-mediated Signaling Pathway Cellular Response To Type II Interferon CARD Domain Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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