VAC14 and EIF2S1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAC14	EIF2S1
Description		VAC14 component of PIKFYVE complex	eukaryotic translation initiation factor 2 subunit alpha
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GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome	Nucleus Cytoplasm Mitochondrion Cytosol Eukaryotic Translation Initiation Factor 2 Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Mitophagy Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Mitochondrial Respirasome Assembly HRI-mediated Signaling Response To Kainic Acid Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	28 interacting genes: ACTN1 ANXA1 CASP3 CASP6 CDC37 CEBPA CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14
Entrez ID		55697	1965
HPRD ID		07660	04881
Ensembl ID		ENSG00000103043	ENSG00000134001
Uniprot IDs		Q08AM6	P05198 Q53XC0
PDB IDs		7K1Y	1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09 7D43 7D44 7D45 7F66 7F67 7NZM 7QP6 7QP7 7SYR 7SYS 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PPL 8QZZ
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	Translational Initiation Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Cytosol Regulation Of Translational Initiation Response To Stress Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Protein Metabolic Process Response To Temperature Stimulus Response To Heat Regulation Of Apoptotic Process Regulation Of Translation Regulation Of Programmed Cell Death Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Regulation Of Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Signal Transduction Oligodendrocyte Development Positive Regulation Of Immune System Process Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Apoptotic Signaling Pathway Translation Protein Serine Kinase Activity Regulation Of Immune Response Intracellular Signal Transduction Response To Glucose Cellular Response To Stress Response To Monosaccharide Protein Serine/threonine Kinase Activity Glial Cell Development Activation Of Immune Response Translation Factor Activity, RNA Binding Response To Carbohydrate Cell Development Protein Kinase C Inhibitor Activity Positive Regulation Of Immune Response Identical Protein Binding Response To Peptide Hormone Cytoplasm Regulation Of Gene Expression Regulation Of Stem Cell Proliferation Negative Regulation Of Translation Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Protein Kinase C Signaling Protein Folding
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