COPRS and HIST2H2AC

Number of citations of the paper that reports this interaction (PMID 18404153)
25

Data Source:
BioGRID (pull down)

		COPRS	HIST2H2AC
Gene Name		coordinator of PRMT5, differentiation stimulator	histone cluster 2, H2ac
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Histone Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Histone H4-R3 Methylation	Biological_process
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CBFB HIST1H2BC HIST2H2AC HIST2H3C HIST4H4 PRMT5 RUNX1 WDR77	65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46
Entrez ID		55352	8338
HPRD ID		13675	09107
Ensembl ID		ENSG00000172301	ENSG00000184260
Uniprot IDs		H9KV77 Q9NQ92	Q16777
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Definitive Hemopoiesis Cellular Macromolecular Complex Assembly Chromatin Organization Chromatin Silencing Spliceosomal SnRNP Assembly DNA Methylation Chromosome Organization Gene Expression Methylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Myeloid Cell Differentiation DNA Modification Gene Silencing Positive Regulation Of Progesterone Secretion Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Regulation Of Transcription, DNA-templated Nucleosome Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Assembly Histone H4-K20 Demethylation Regulation Of Progesterone Secretion Nucleosome Organization Nucleobase-containing Compound Metabolic Process Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Hair Follicle Cell Proliferation Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of Gene Expression Regulation Of Myeloid Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Megakaryocyte Differentiation DNA Packaging Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Cellular Component Assembly Negative Regulation Of Granulocyte Differentiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Nitrogen Compound Metabolic Process Myeloid Cell Differentiation	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly
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