COPRS

Description		coordinator of PRMT5 and differentiation stimulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Histone Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Muscle Organ Development
Pathways		RMTs methylate histone arginines
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) High chromosomal aberration frequency (chromosome type) ( 31586183) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Myocardial infarction ( 33532862) Urinary albumin excretion ( 32277301)
Interacting Genes		5 interacting genes: CBFB H3-4 H4C16 PRMT5 RUNX1
Entrez ID		55352
HPRD ID		13675
Ensembl ID		ENSG00000172301
Uniprot IDs		H9KV77 Q9NQ92
PDB IDs
Enriched GO Terms of Interacting Partners?		Core-binding Factor Complex Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Protein Heterodimerization Activity Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Development Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Developmental Process Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Hemopoiesis Positive Regulation Of Cell Development Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Multicellular Organismal Development Regulation Of CD4-positive, Alpha-beta T Cell Activation Structural Constituent Of Chromatin Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Nucleosome Assembly Ossification Negative Regulation Of Hemopoiesis Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Regeneration Chromatin Remodeling Nucleosome Chromosome Nucleosome Organization Peptidyl-arginine N-methylation Positive Regulation Of Lymphocyte Differentiation Nucleoplasm Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Negative Regulation Of Lymphocyte Activation DNA Binding Hemopoiesis Chromosome, Telomeric Region Chromatin Organization Cardiac Muscle Tissue Regeneration
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