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PSMD11 and ZHX1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMD11
ZHX1
Gene Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
zinc fingers and homeoboxes 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Molecular Function
Protein Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome Assembly
Small Molecule Metabolic Process
Stem Cell Differentiation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
33 interactors:
APP
BRD7
CCDC90B
CCSER2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRMT6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
50 interactors:
AKR1C3
AKT1
ATXN1
BARD1
BCL2L1
BHLHE40
BID
CHD3
CREB1
CSNK2A1
DDX39B
DLST
DYNLL1
EFNA2
ELL
GADD45A
GNG11
GSK3B
HSPE1
IDH1
LAMA4
LYAR
MPHOSPH6
NACA
NFYA
PAFAH1B3
PEX14
PIAS4
PIGC
PNP
PRPF40A
PSMD11
SAT1
SERPINB9
SUMO2
TAL1
TALDO1
TARDBP
TERF1
TNFRSF10C
TOLLIP
TP53
UTP3
VIM
WDR33
ZHX2
ZHX3
ZMYND11
ZNF33B
ZYX
Entrez ID
5717
11244
HPRD ID
05119
10379
Ensembl ID
ENSG00000108671
ENSG00000165156
Uniprot IDs
O00231
Q9UKY1
PDB IDs
2ECB
2GHF
2LY9
3NAR
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Negative Regulation Of Biosynthetic Process
Transcription, DNA-templated
Cellular Response To Transforming Growth Factor Beta Stimulus
RNA Biosynthetic Process
RNA Metabolic Process
Response To Transforming Growth Factor Beta
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
SMAD Protein Complex Assembly
Negative Regulation Of Gene Expression
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryonic Pattern Specification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Response To Growth Factor
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Mesonephros Development
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Primary MiRNA Processing
Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Cell Proliferation
Growth
Positive Regulation Of Gene Expression
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
SMAD Protein Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Developmental Growth
Negative Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Cell Death
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Cell Death
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Viral Process
Regulation Of Mitochondrion Organization
Negative Regulation Of Biosynthetic Process
Apoptotic Process
RNA Metabolic Process
Programmed Cell Death
Cell Death
Death
Cellular Metabolic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrion Organization
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle
Gene Expression
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Process
Transcription, DNA-templated
Negative Regulation Of Gene Expression
Cell Cycle
Negative Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Rhythmic Process
Negative Regulation Of Cell Cycle
Developmental Process
Positive Regulation Of Protein Metabolic Process
Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Cell Cycle Process
Regulation Of Cell Cycle Process
Regulation Of Proteolysis
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Nitrogen Compound Metabolic Process
Cellular Process
Negative Regulation Of Transcription, DNA-templated
Tagcloud
?
199a
3p
accumulating
bound
carcinogenesis
direct
dramatically
epigenetic
fingers
gastric
gc
homeoboxes
inversely
involve
micrornas
mir
mirnas
n87
nci
oncogenic
regulator
regulators
restoring
sgc
suppressed
untranslated
upregulated
utr
zinc
Tagcloud (Difference)
?
199a
3p
accumulating
bound
carcinogenesis
direct
dramatically
epigenetic
fingers
gastric
gc
homeoboxes
inversely
involve
micrornas
mir
mirnas
n87
nci
oncogenic
regulator
regulators
restoring
sgc
suppressed
untranslated
upregulated
utr
zinc
Tagcloud (Intersection)
?