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PSMD11 and EEF1A1
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMD11
EEF1A1
Description
proteasome 26S subunit, non-ATPase 11
eukaryotic translation elongation factor 1 alpha 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Protein-containing Complex
Secretory Granule Lumen
Ficolin-1-rich Granule Lumen
Extracellular Region
Extracellular Space
Nucleus
Nucleolus
Cytoplasm
Cytosol
Ribosome
Eukaryotic Translation Elongation Factor 1 Complex
Plasma Membrane
Membrane
Cytosolic Ribosome
Cortical Actin Cytoskeleton
Ruffle Membrane
Secretory Granule Lumen
Extracellular Exosome
Cytoplasmic Side Of Lysosomal Membrane
Ficolin-1-rich Granule Lumen
Molecular Function
Structural Molecule Activity
Protein Binding
TRNA Binding
Nucleotide Binding
RNA Binding
Translation Elongation Factor Activity
GTPase Activity
Protein Binding
GTP Binding
Hydrolase Activity
Kinase Activator Activity
Kinase Binding
Protein Kinase Binding
Molecular Adaptor Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasome Assembly
Stem Cell Differentiation
Translation
Translational Elongation
Host-mediated Activation Of Viral Genome Replication
Cellular Response To Epidermal Growth Factor Stimulus
Regulation Of Chaperone-mediated Autophagy
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Eukaryotic Translation Elongation
Eukaryotic Translation Elongation
Peptide chain elongation
HSF1 activation
Neutrophil degranulation
Protein methylation
Chaperone Mediated Autophagy
SARS-CoV-1 modulates host translation machinery
Drugs
Zinc
Guanosine-5'-Diphosphate
Copper
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Schizophrenia (
33169155
)
Interacting Genes
38 interacting genes:
APP
BRD7
CCDC90B
CCSER2
CDC42
CEBPA
COPS2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRKAB2
PRKACA
PRMT6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
144 interacting genes:
ABTB2
ACTB
ALPL
ANKRD24
ANXA7
APLP1
AQP2
ARIH2
AXIN1
BBS1
BBS2
BBS4
BRMS1
BTBD2
CASP2
CCL18
CDC25A
CDKN1A
CEBPA
CKS2
CLIC6
COX17
CRADD
CRCT1
CREBBP
CSRP2
CTIF
DARS1
DCTN1
DIABLO
DLEU1
DNMT1
DNMT3A
DUSP7
DYNLL1
DYSF
EIF3F
EP300
EXOSC4
FAS
GADD45A
GADD45G
HOXA1
HSPB2
HSPE1
HTRA2
IKBKG
IMMT
ITGB1BP1
ITSN1
KCNE3
KIF1B
LAMA4
LAMTOR1
LAMTOR5
LSM3
MAD2L1BP
MAGED2
MAP3K14
MAPK14
MLLT3
MNAT1
MRM1
MRPL42
MTRNR2L1
MYOC
NEU1
NRAS
NREP
OGT
ORMDL3
PABPC4
PAEP
PAFAH1B3
PAPSS1
PCDHA4
PFN2
PHYHIP
PKN2
PLAUR
PLCG1
POLE2
POLR2C
PQBP1
PRKCD
PSG9
PSMD11
PTPN4
PTPRCAP
PTPRF
RAB27A
RAP2A
RFC5
RGS12
RND1
RNF10
RPA2
RPLP1
RRAS
RSRC1
SARS2
SDHAF2
SERPINB5
SERPINB9
SF3B4
SFN
SHBG
SMAD2
SMAD4
SMN1
SPATS2L
SPP1
SSR1
STAT6
STMN2
SULT1E1
SUMO2
TAF9
TGIF1
TK1
TMPRSS3
TNFSF11
TP53BP2
TPT1
TRDMT1
TSC2
TSPY1
TSPYL2
TTLL12
TTR
TXNIP
UBQLN4
USP40
VHL
WARS1
WEE2-AS1
XPO5
XRN2
YJU2B
YWHAG
ZBTB16
ZCCHC10
ZNF24
ZPR1
Entrez ID
5717
1915
HPRD ID
05119
00559
Ensembl ID
ENSG00000108671
ENSG00000156508
Uniprot IDs
O00231
P68104
Q6IPS9
PDB IDs
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
3C5J
6ZMO
8G60
8G6J
Enriched GO Terms of Interacting Partners
?
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Transforming Growth Factor Beta Receptor Signaling Pathway
I-SMAD Binding
SMAD Protein Signal Transduction
Negative Regulation Of Macromolecule Biosynthetic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Embryonic Pattern Specification
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Metabolic Process
Cardiac Conduction System Development
Cell Surface Receptor Signaling Pathway
Transcription Regulator Complex
Protein-containing Complex
Intracellular Signaling Cassette
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
DEAD/H-box RNA Helicase Binding
Regulation Of MiRNA Transcription
Chromatin Binding
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity
Regulation Of MiRNA Metabolic Process
Nucleotide-activated Protein Kinase Complex
Positive Regulation Of Cell Differentiation
Ureteric Bud Development
Co-SMAD Binding
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Differentiation
Primary MiRNA Processing
Signal Transduction
Mesonephric Tubule Development
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Mesonephric Epithelium Development
Gastrulation
Homomeric SMAD Protein Complex
Nucleus
Response To Growth Factor
Protein Kinase Binding
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Gene Expression
Response To Glucose
Cytoplasm
Apoptotic Process
Cell Death
Programmed Cell Death
Regulation Of Programmed Cell Death
Cytosol
Negative Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Negative Regulation Of Kinase Activity
Negative Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Phosphorylation
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Apoptotic Signaling Pathway
BBSome
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
TORC1 Signaling
Protein-containing Complex
Nucleus
Macromolecule Biosynthetic Process
Melanosome Transport
Tau Protein Binding
Regulation Of Developmental Process
RNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Establishment Of Melanosome Localization
Pigment Granule Transport
Negative Regulation Of Protein Phosphorylation
Cellular Response To Stress
Melanosome Localization
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Macromolecule Metabolic Process
Positive Regulation Of Apoptotic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pigment Granule Localization
Mitochondrial Intermembrane Space
Nucleoplasm
Protein Binding
Negative Regulation Of Catalytic Activity
Histone H3K27 Acetyltransferase Activity
Negative Regulation Of Phosphate Metabolic Process
TOR Signaling
Positive Regulation Of TOR Signaling
Regulation Of Phosphorus Metabolic Process
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