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PSMD11 and EEF1A1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMD11
EEF1A1
Gene Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
eukaryotic translation elongation factor 1 alpha 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Extracellular Space
Nucleus
Nucleolus
Cytoplasm
Cytosol
Eukaryotic Translation Elongation Factor 1 Complex
Plasma Membrane
Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Translation Elongation Factor Activity
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Binding
Poly(A) RNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome Assembly
Small Molecule Metabolic Process
Stem Cell Differentiation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Translation
Translational Elongation
Gene Expression
Cellular Protein Metabolic Process
Cellular Response To Epidermal Growth Factor Stimulus
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
HSF1 activation
Translation
Cellular response to heat stress
Peptide chain elongation
Eukaryotic Translation Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions
33 interactors:
APP
BRD7
CCDC90B
CCSER2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRMT6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
123 interactors:
ABTB2
ACTB
ALPL
ANKRD24
ANXA7
APLP1
ARIH2
AXIN1
BBS1
BBS2
BBS4
BRMS1
BTBD2
CASP2
CCDC130
CCL18
CDC25A
CDKN1A
CKS2
COX17
CRADD
CRCT1
CSRP2
DARS
DIABLO
DLEU1
DUSP7
DYNLL1
EIF3F
EXOSC4
FAS
GADD45A
GADD45G
GSK3B
HSPE1
HTRA2
IKBKG
IMMT
ITGB1BP1
ITSN1
KCNE3
KIF1B
KRAS
LAMA4
LAMTOR1
LAMTOR5
LSM3
MAD2L1BP
MAGED2
MAP3K14
MAPK14
MLLT3
MNAT1
MRM1
MRPL42
MTRNR2L1
MYOC
NEU1
NRAS
NREP
ORMDL3
PABPC4
PAEP
PAFAH1B3
PAPSS1
PCDHA4
PFN2
PHYHIP
PKN2
PLAUR
PLCG1
POLE2
POLR2C
PQBP1
PRKCD
PSG9
PSMD11
PTPN4
PTPRCAP
RAB27A
RAP2A
RBBP8
RFC5
RGS12
RNF10
RPA2
RPLP1
RRAS
RSRC1
SARS2
SDHAF2
SERPINB9
SFN
SHBG
SMAD2
SMAD4
SMN1
SNCA
SPP1
SSR1
STAT6
STMN2
SULT1E1
TAF9
TGIF1
TK1
TMPRSS3
TNFSF11
TP53BP2
TPT1
TRDMT1
TSPY1
TSPYL2
TTR
UBQLN4
WARS
XPO5
XRN2
YWHAG
ZBTB16
ZCCHC10
ZNF24
ZPR1
Entrez ID
5717
1915
HPRD ID
05119
00559
Ensembl ID
ENSG00000108671
ENSG00000156508
Uniprot IDs
O00231
P68104
Q6IPS9
PDB IDs
1SYW
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Negative Regulation Of Biosynthetic Process
Transcription, DNA-templated
Cellular Response To Transforming Growth Factor Beta Stimulus
RNA Biosynthetic Process
RNA Metabolic Process
Response To Transforming Growth Factor Beta
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
SMAD Protein Complex Assembly
Negative Regulation Of Gene Expression
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryonic Pattern Specification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Response To Growth Factor
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Mesonephros Development
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Primary MiRNA Processing
Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Cell Proliferation
Growth
Positive Regulation Of Gene Expression
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
SMAD Protein Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Developmental Growth
Apoptotic Process
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cell Death
Death
Regulation Of Phosphorylation
Developmental Process
Regulation Of Phosphorus Metabolic Process
Response To Stimulus
Regulation Of Protein Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Cell Differentiation
Anatomical Structure Development
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Organic Substance
Regulation Of Cell Death
Multicellular Organismal Development
Regulation Of Apoptotic Process
Cellular Response To Stimulus
Response To Stress
Cellular Response To Growth Factor Stimulus
Response To External Stimulus
Positive Regulation Of Protein Modification Process
Regulation Of Signaling
Cellular Response To Stress
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Positive Regulation Of Catalytic Activity
System Development
Positive Regulation Of Phosphorylation
Positive Regulation Of Cell Death
Regulation Of MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Nervous System Development
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transferase Activity
Apoptotic Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Kinase Activity
Tagcloud
?
akap6
atf7
atxn1
bmpr2
categorize
deltan
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
shank1
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Difference)
?
akap6
atf7
atxn1
bmpr2
categorize
deltan
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
shank1
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Intersection)
?