Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
PSMD11 and EEF1G
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
PSMD11
EEF1G
Gene Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
eukaryotic translation elongation factor 1 gamma
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Nucleus
Cytosol
Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Translation Elongation Factor Activity
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome Assembly
Small Molecule Metabolic Process
Stem Cell Differentiation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Translation
Translational Elongation
Response To Virus
Gene Expression
Cellular Protein Metabolic Process
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Translation
Eukaryotic Translation Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions
33 interactors:
APP
BRD7
CCDC90B
CCSER2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRMT6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
87 interactors:
ABCC9
ADAP2
AKT1
ARF1
ARIH2
C11orf58
C1orf174
CARS
CBX8
CCDC106
CCT7
CDC42
CDK2AP2
CDK5RAP2
CHFR
CRELD1
CSTF2
CXCL13
DKC1
DLEU1
DRD3
ECH1
EEF1B2
EEF1D
EEF1DP3
EFNA1
EGFR
EID2B
ENOX1
FAM195A
FEN1
FOXG1
GADD45A
GADD45G
GET4
GSK3B
GSTO1
HARS
HDAC5
HLTF
HMOX2
HNRNPH3
ILF2
KARS
KLHL18
LARS
LZTS1
MED31
MLH1
MTNR1A
MVD
NADK
NCK2
NDRG1
NUDT21
NUDT3
NUP85
OGFOD2
PDCD5
PHACTR3
PLEKHA4
PLGRKT
PSMD11
PTK2
PTPN4
PTPRS
RBM6
RECQL5
RGL2
RPL4P5
RPS28
SAT1
SKIL
SNAPIN
SNRPD2
TNNT1
TP53I3
TRIB3
TRIM55
TRIM63
TUBB3
UCHL5
WDR33
YWHAG
ZBED8
ZDHHC17
ZNF24
Entrez ID
5717
1937
HPRD ID
05119
11745
Ensembl ID
ENSG00000108671
ENSG00000254772
Uniprot IDs
O00231
P26641
Q53YD7
PDB IDs
1PBU
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Negative Regulation Of Biosynthetic Process
Transcription, DNA-templated
Cellular Response To Transforming Growth Factor Beta Stimulus
RNA Biosynthetic Process
RNA Metabolic Process
Response To Transforming Growth Factor Beta
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
SMAD Protein Complex Assembly
Negative Regulation Of Gene Expression
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryonic Pattern Specification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Response To Growth Factor
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Mesonephros Development
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Primary MiRNA Processing
Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Cell Proliferation
Growth
Positive Regulation Of Gene Expression
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
SMAD Protein Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Developmental Growth
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Macromolecule Biosynthetic Process
Cellular Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Biosynthetic Process
Positive Regulation Of Signal Transduction
Cell Cycle Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Intracellular Transport
Regulation Of Cell Development
Chemotaxis
Regulation Of Protein Kinase Activity
Cell Cycle
Regulation Of Endothelial Cell Migration
Positive Regulation Of Mitochondrion Organization
Regulation Of Kinase Activity
Translation
Negative Regulation Of Transferase Activity
Regulation Of Neuron Differentiation
Negative Regulation Of Protein Kinase Activity
Negative Regulation Of Protein Phosphorylation
Regulation Of Neurogenesis
Positive Regulation Of Transferase Activity
Regulation Of Intracellular Transport
Cellular Response To Mechanical Stimulus
Nervous System Development
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Kinase Activity
MRNA Polyadenylation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Protein Binding
Regulation Of Epithelial Cell Migration
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Protein Metabolic Process
MRNA 3'-end Processing
Response To Growth Factor
Regulation Of Signal Transduction
Mitotic Cell Cycle
Immune System Process
Regulation Of Cell Projection Organization
Response To UV-A
Regulation Of Catalytic Activity
Tagcloud
?
4egi
antiporter
antitumoral
apparatus
atf4
attenuation
bip
client
consequent
cyclophilin
cystine
eef1a
eif4a
favoring
filters
gcn2
hsp
migrate
nascent
pores
proteostasis
ribavirin
ribosomes
sensitizes
sorcin
tbp7
transwell
trap1
xct
Tagcloud (Difference)
?
4egi
antiporter
antitumoral
apparatus
atf4
attenuation
bip
client
consequent
cyclophilin
cystine
eef1a
eif4a
favoring
filters
gcn2
hsp
migrate
nascent
pores
proteostasis
ribavirin
ribosomes
sensitizes
sorcin
tbp7
transwell
trap1
xct
Tagcloud (Intersection)
?