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PSMD11 and HAP1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
PSMD11
HAP1
Gene Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
huntingtin-associated protein 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Nucleus
Mitochondrion
Lysosome
Autophagic Vacuole
Endoplasmic Reticulum
Cytoskeleton
Synaptic Vesicle
Actin Cytoskeleton
Inclusion Body
Cell Junction
Axon
Molecular Function
Protein Binding
Protein Binding
Ion Channel Binding
Brain-derived Neurotrophic Factor Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome Assembly
Small Molecule Metabolic Process
Stem Cell Differentiation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Exocytosis
Autophagy
Synaptic Transmission
Brain Development
Anterograde Axon Cargo Transport
Retrograde Axon Cargo Transport
Protein Localization
Protein Transport
Regulation Of Exocytosis
Cerebellum Development
Hypothalamus Cell Differentiation
Cell Projection Organization
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Positive Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Neurogenesis
Negative Regulation Of Beta-amyloid Formation
Regulation Of Organelle Transport Along Microtubule
Positive Regulation Of Nonmotile Primary Cilium Assembly
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Esophageal cancer (squamous cell) (
22960999
)
Protein-Protein Interactions
33 interactors:
APP
BRD7
CCDC90B
CCSER2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRMT6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
68 interactors:
APLP1
ATP5J2
BARD1
BRD7
C7orf25
C8orf33
CBX8
CCDC113
CDC73
CDK5RAP2
COL9A2
CRIP1
DCTN1
DDX49
DEFB1
EIF3E
FAM173A
FEZ1
GADD45G
GIT1
GLTSCR2
GPRASP2
HGS
HMOX2
HSPA4
HTT
IMMT
ING5
KAT5
KAT7
KATNBL1
KBTBD7
KPNA2
LRIF1
LUC7L2
MPP3
MRPS9
NAP1L5
NDUFB9
NEUROD1
NIPSNAP3A
PABPC4
PCM1
PDCD7
PFDN1
PPID
PPOX
PSMD11
RER1
RIF1
RPS10
RPS25
SNAPIN
SRSF4
STX5
TAF1D
TBP
TIMM17A
TNNT1
TNNT3
TOMM20
TSPYL1
UTP3
VIM
ZNF20
ZNF24
ZNF33B
ZNF691
Entrez ID
5717
9001
HPRD ID
05119
02972
Ensembl ID
ENSG00000108671
ENSG00000173805
Uniprot IDs
O00231
P54257
PDB IDs
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Negative Regulation Of Biosynthetic Process
Transcription, DNA-templated
Cellular Response To Transforming Growth Factor Beta Stimulus
RNA Biosynthetic Process
RNA Metabolic Process
Response To Transforming Growth Factor Beta
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
SMAD Protein Complex Assembly
Negative Regulation Of Gene Expression
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryonic Pattern Specification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Response To Growth Factor
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Mesonephros Development
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Primary MiRNA Processing
Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Cell Proliferation
Growth
Positive Regulation Of Gene Expression
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
SMAD Protein Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Developmental Growth
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Gene Expression
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cytoplasmic Transport
Intracellular Transport
Establishment Of Localization In Cell
Establishment Of Protein Localization To Organelle
RNA Biosynthetic Process
Organelle Organization
Protein Localization To Organelle
Viral Process
Protein Targeting
Negative Regulation Of Cellular Metabolic Process
Cellular Localization
Regulation Of Metabolic Process
Regulation Of Gene Expression
Cellular Process
Cellular Macromolecule Biosynthetic Process
Transcription, DNA-templated
Macromolecule Biosynthetic Process
Mitochondrial Transport
Regulation Of Nitrogen Compound Metabolic Process
Intracellular Protein Transport
Actin-myosin Filament Sliding
Muscle Filament Sliding
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Cellular Protein Localization
Biosynthetic Process
Protein Transport
Endosomal Transport
Cellular Metabolic Process
Actin-mediated Cell Contraction
Protein Localization
Establishment Of Protein Localization
Microtubule-based Transport
Cytoskeleton-dependent Intracellular Transport
MRNA Metabolic Process
Chromatin Organization
Cell Cycle
Regulation Of Cell Cycle
Protein Transmembrane Transport
Actin Filament-based Movement
Organelle Localization
Protein Targeting To Mitochondrion
Negative Regulation Of Neurogenesis
Tagcloud
?
autism
axons
cognition
elucidated
hippocampal
huntingtin
impairs
knockdown
morphogenesis
mtorc1
neurons
partner
phenotypes
polarity
positioning
profoundly
proteomics
pyramidal
recapitulate
reflected
s6
specification
supernumerary
suppresses
tsc
tsc1
tsc2
tuberous
uncover
Tagcloud (Difference)
?
autism
axons
cognition
elucidated
hippocampal
huntingtin
impairs
knockdown
morphogenesis
mtorc1
neurons
partner
phenotypes
polarity
positioning
profoundly
proteomics
pyramidal
recapitulate
reflected
s6
specification
supernumerary
suppresses
tsc
tsc1
tsc2
tuberous
uncover
Tagcloud (Intersection)
?