OAS1 and COG6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OAS1	COG6
Description		2'-5'-oligoadenylate synthetase 1	component of oligomeric golgi complex 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Ribosome Membrane	Golgi Membrane Golgi Apparatus Membrane Golgi Transport Complex Trans-Golgi Network Membrane
	Molecular Function	Nucleotide Binding 2'-5'-oligoadenylate Synthetase Activity RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding	Protein Binding
	Biological Process	Immune System Process Glucose Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Glucose Homeostasis Defense Response To Bacterium Surfactant Homeostasis Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of IP-10 Production Defense Response To Other Organism Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Cellular Respiration Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Glycosylation
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs		Cysteine-S-acetamide
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)	Asthma ( 32296059 31959851 30929738) Asthma (adult onset) ( 30929738) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 31562340) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Psoriasis ( 25903422 18369459) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		11 interacting genes: ACTN1 BBS4 BUD23 COG6 EXOC5 GOLGA2 HOOK2 PRMT6 RPL30 RUFY1 TRIM27	64 interacting genes: ARHGEF5 ATXN7 BAIAP2 BCL10 CCDC116 CCDC120 CCDC187 CCDC92 CNN1 CNNM3 CSRP2 CUL5 DOCK8 DRC4 FAM110A FAM90A1 FANCG FNDC11 GEM GOLGA2 GRAP2 IGFN1 KANK2 LGALS14 LMO4 MCM7 MFAP1 MRI1 NDUFA5 NEK6 NTAQ1 NUP58 OAS1 PLEKHA2 POM121 PPP1R18 PSMA1 PSMB1 QARS1 RAB3IL1 RAB6B RSPH14 RTP5 RUNX1T1 SAXO4 SCNM1 SMARCD1 SNAI1 SNRPB SPG21 SYCP2L SYT17 TBC1D22B TMSB4X TSC1 TSGA10 TSHZ3 TSNAX TTC7B UFSP1 WASHC3 ZBTB16 ZFC3H1 ZNF417
Entrez ID		4938	57511
HPRD ID		08879	08445
Ensembl ID		ENSG00000089127	ENSG00000133103
Uniprot IDs		A0A6Q8PHR1 A0A7P0T8F9 A0A7P0T9Q4 A0A7P0Z4N8 H0YIB8 P00973	A0A140VJG7 Q9Y2V7
PDB IDs		4IG8
Enriched GO Terms of Interacting Partners?		Protein Transport Golgi Vesicle Transport Vesicle-mediated Transport Establishment Of Protein Localization Organelle Organization Intracellular Protein Localization Centrosome Cycle Non-motile Cilium Assembly Endosomal Transport Histone H2AR3 Methyltransferase Activity Mitotic Cytokinesis Platelet Morphogenesis Structural Constituent Of Postsynapse Cytoskeleton-dependent Cytokinesis Microtubule Organizing Center Organization Establishment Of Localization In Cell Cellular Localization Negative Regulation Of Catabolic Process Retrograde Transport, Endosome To Golgi Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RRNA (guanine-N7)-methylation Negative Regulation Of Autophagy Cytoskeleton Organization Microtubule Cytoskeleton Organization Sensory Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Glycosylation Golgi Organization Identical Protein Binding Supramolecular Fiber Organization Cytosolic Transport FHF Complex Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity	Protein Binding
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