OAS1 and RPL30

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		OAS1	RPL30
Description		2'-5'-oligoadenylate synthetase 1	ribosomal protein L30
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Ribosome Membrane	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding 2'-5'-oligoadenylate Synthetase Activity RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Immune System Process Glucose Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Glucose Homeostasis Defense Response To Bacterium Surfactant Homeostasis Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of IP-10 Production Defense Response To Other Organism Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Cellular Respiration Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Cytoplasmic Translation Translation Killing Of Cells Of Another Organism Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Cysteine-S-acetamide
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)	Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: ACTN1 BBS4 BUD23 COG6 EXOC5 GOLGA2 HOOK2 PRMT6 RPL30 RUFY1 TRIM27	16 interacting genes: APP CASP2 DUX4 ERCC6 FAM120B G0S2 IL7R MAP2K7 MAP3K14 NEDD4L NFKB2 OAS1 OGT PTEN USP40 ZFAND2A
Entrez ID		4938	6156
HPRD ID		08879	01595
Ensembl ID		ENSG00000089127	ENSG00000156482
Uniprot IDs		A0A6Q8PHR1 A0A7P0T8F9 A0A7P0T9Q4 A0A7P0Z4N8 H0YIB8 P00973	P62888
PDB IDs		4IG8	3VI6 4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein Transport Golgi Vesicle Transport Vesicle-mediated Transport Establishment Of Protein Localization Organelle Organization Intracellular Protein Localization Centrosome Cycle Non-motile Cilium Assembly Endosomal Transport Histone H2AR3 Methyltransferase Activity Mitotic Cytokinesis Platelet Morphogenesis Structural Constituent Of Postsynapse Cytoskeleton-dependent Cytokinesis Microtubule Organizing Center Organization Establishment Of Localization In Cell Cellular Localization Negative Regulation Of Catabolic Process Retrograde Transport, Endosome To Golgi Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RRNA (guanine-N7)-methylation Negative Regulation Of Autophagy Cytoskeleton Organization Microtubule Cytoskeleton Organization Sensory Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Glycosylation Golgi Organization Identical Protein Binding Supramolecular Fiber Organization Cytosolic Transport FHF Complex Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity	Intracellular Signal Transduction Positive Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Rhythmic Process Cytosol Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Proteolysis Positive Regulation Of Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Catabolic Process Molecular Function Activator Activity Positive Regulation Of Signal Transduction Dendritic Spine Reproductive Behavior Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Peptidyl-serine Phosphorylation Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Hemopoiesis Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Neuron Projection Organization Cellular Developmental Process Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Response To Mechanical Stimulus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Neuron Projection Development Modulation Of Excitatory Postsynaptic Potential
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