OAS1 and RPL30

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		OAS1	RPL30
Gene Name		2-5-oligoadenylate synthetase 1, 40/46kDa	ribosomal protein L30
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Glucose Metabolic Process Purine Nucleotide Biosynthetic Process Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Glucose Homeostasis Negative Regulation Of Viral Genome Replication Protein Oligomerization Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Glycemic traits ( 23575436) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		6 interactors: ACTN1 EXOC5 PRMT6 RPL30 TRIM27 WBSCR22	13 interactors: APP CASP2 FAM120B G0S2 IL7R MAP2K7 MAP3K14 NEDD4L NFKB2 OAS1 RPL13A RPS11 ZFAND2A
Entrez ID		4938	6156
HPRD ID		08879	01595
Ensembl ID		ENSG00000089127	ENSG00000156482
Uniprot IDs		P00973	P62888
PDB IDs		4IG8	3J3B 3VI6
Enriched GO Terms of Interacting Partners?		Secretion By Cell Organelle Organization Secretion Histone H3-R2 Methylation Negative Regulation Of Interleukin-2 Secretion Protein Localization Establishment Of Localization In Cell Protein Localization To Tight Junction RNA Biosynthetic Process Cellular Localization Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Protein Localization To Cell Junction Actin Filament Organization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Exocytosis Histone H4-R3 Methylation Protein Transport Negative Regulation Of Viral Release From Host Cell Vesicle-mediated Transport RNA Metabolic Process Establishment Of Protein Localization Peptidyl-arginine N-methylation Methylation Actin Crosslink Formation Intracellular Transport Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Gene Expression Histone Arginine Methylation Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Peptidyl-arginine Methylation Regulation Of Calcium Ion Import Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Viral Process Focal Adhesion Assembly Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Actin Cytoskeleton Organization Chromatin Modification Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Actin Filament-based Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Arp2/3 Complex-mediated Actin Nucleation	Immune Response Response To Cytokine Cellular Response To Stimulus Innate Immune Response Immune System Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Viral Life Cycle Response To Organic Substance Response To Abiotic Stimulus NIK/NF-kappaB Signaling Cellular Response To Organic Substance Response To Stimulus Positive Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Formation Of Translation Preinitiation Complex MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signaling MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Cell Communication Positive Regulation Of Neuron Death Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Response To Osmotic Stress Viral Transcription Positive Regulation Of Immune System Process Follicular Dendritic Cell Differentiation Synaptic Growth At Neuromuscular Junction Interleukin-7-mediated Signaling Pathway Positive Regulation Of Caveolin-mediated Endocytosis Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Apoptotic Process
Tagcloud ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase	ark avian avoid axl base c2 changing chicken confusion counterpart domains eyk fn ig moderately name oncogene pairs proto ptk renamed retrovirus ryk spleen subfamily transmembrane truncated ufo v
Tagcloud (Difference) ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase	ark avian avoid axl base c2 changing chicken confusion counterpart domains eyk fn ig moderately name oncogene pairs proto ptk renamed retrovirus ryk spleen subfamily transmembrane truncated ufo v
Tagcloud (Intersection) ?