OAS1

Gene Name		2-5-oligoadenylate synthetase 1, 40/46kDa
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Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Glucose Metabolic Process Purine Nucleotide Biosynthetic Process Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Glucose Homeostasis Negative Regulation Of Viral Genome Replication Protein Oligomerization Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Glycemic traits ( 23575436) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-protein Interactions		6 interactors: ACTN1 EXOC5 PRMT6 RPL30 TRIM27 WBSCR22
Entrez ID		4938
HPRD ID		08879
Ensembl ID		ENSG00000089127
Uniprot IDs		P00973
PDB IDs		4IG8
Enriched GO Terms of Interacting Partners?		Secretion By Cell Organelle Organization Secretion Histone H3-R2 Methylation Negative Regulation Of Interleukin-2 Secretion Protein Localization Establishment Of Localization In Cell Protein Localization To Tight Junction RNA Biosynthetic Process Cellular Localization Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Protein Localization To Cell Junction Actin Filament Organization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Exocytosis Histone H4-R3 Methylation Protein Transport Negative Regulation Of Viral Release From Host Cell Vesicle-mediated Transport RNA Metabolic Process Establishment Of Protein Localization Peptidyl-arginine N-methylation Methylation Actin Crosslink Formation Intracellular Transport Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Gene Expression Histone Arginine Methylation Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Peptidyl-arginine Methylation Regulation Of Calcium Ion Import Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Viral Process Focal Adhesion Assembly Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Actin Cytoskeleton Organization Chromatin Modification Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Actin Filament-based Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Arp2/3 Complex-mediated Actin Nucleation
Tagcloud ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase