OAS1 and ACTN1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OAS1	ACTN1
Gene Name		2-5-oligoadenylate synthetase 1, 40/46kDa	actinin, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Metal Ion Binding	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding
	Biological Process	Glucose Metabolic Process Purine Nucleotide Biosynthetic Process Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Glucose Homeostasis Negative Regulation Of Viral Genome Replication Protein Oligomerization Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Glycemic traits ( 23575436) Response to fenofibrate (adiponectin levels) ( 23149075)	Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		6 interactors: ACTN1 EXOC5 PRMT6 RPL30 TRIM27 WBSCR22	70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX
Entrez ID		4938	87
HPRD ID		08879	00020
Ensembl ID		ENSG00000089127	ENSG00000072110
Uniprot IDs		P00973	P12814
PDB IDs		4IG8	2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Secretion By Cell Organelle Organization Secretion Histone H3-R2 Methylation Negative Regulation Of Interleukin-2 Secretion Protein Localization Establishment Of Localization In Cell Protein Localization To Tight Junction RNA Biosynthetic Process Cellular Localization Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Protein Localization To Cell Junction Actin Filament Organization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Exocytosis Histone H4-R3 Methylation Protein Transport Negative Regulation Of Viral Release From Host Cell Vesicle-mediated Transport RNA Metabolic Process Establishment Of Protein Localization Peptidyl-arginine N-methylation Methylation Actin Crosslink Formation Intracellular Transport Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Gene Expression Histone Arginine Methylation Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Peptidyl-arginine Methylation Regulation Of Calcium Ion Import Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Viral Process Focal Adhesion Assembly Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Actin Cytoskeleton Organization Chromatin Modification Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Actin Filament-based Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Arp2/3 Complex-mediated Actin Nucleation	Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development
Tagcloud ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?		5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?