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PPP2CB and MLH3
Number of citations of the paper that reports this interaction (PubMedID
24412244
)
0
Data Source:
BioGRID
(two hybrid)
PPP2CB
MLH3
Description
protein phosphatase 2 catalytic subunit beta
mutL homolog 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Chromosome
Cytoplasm
Cytosol
Cytoskeleton
FAR/SIN/STRIPAK Complex
Condensed Chromosome
Condensed Nuclear Chromosome
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chiasma
Mismatch Repair Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Hydrolase Activity
Transmembrane Transporter Binding
Metal Ion Binding
Tau Protein Binding
Chromatin Binding
Satellite DNA Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Centromeric DNA Binding
Mismatched DNA Binding
ATP-dependent DNA Damage Sensor Activity
Biological Process
Mitotic Cell Cycle
Protein Dephosphorylation
Apoptotic Mitochondrial Changes
Response To Lead Ion
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Microtubule Polymerization
Response To Endoplasmic Reticulum Stress
Response To Hydrogen Peroxide
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Regulation Of Neurofibrillary Tangle Assembly
DNA Repair
Mismatch Repair
DNA Damage Response
Synaptonemal Complex Assembly
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiosis I
Intracellular Protein Localization
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
PKR-mediated signaling
Meiotic recombination
Drugs
Vitamin E
Diseases
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS
Daytime sleep phenotypes (
27126917
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Inflammatory bowel disease (
23128233
)
Mood instability (
29187730
)
Refractive error (
32231278
)
Interacting Genes
41 interacting genes:
ACP5
AXIN1
BHLHE41
BUB1
C22orf39
DOCK7
DYNLT2B
EGFR
GAD1
GSTA1
HK3
KRAS
LCMT1
MAK
MAPT
MID1
MLH1
MLH3
NRAS
PACS1
PDGFRL
PLXNA3
PMS2
PRKCB
PTPRJ
RAF1
RELA
RPLP1
SGO1
SMAD4
SRC
STK11
TAB1
TAB2
TGFBR2
TIPRL
TLX1
TRMT61B
UBC
ZFP28
ZNF775
48 interacting genes:
AKT1
ALDOB
ANP32B
AOPEP
AR
BAAT
CCDC180
CDC14B
CDK8
CTSV
CYLC2
DVL1
EXO1
FANCC
FBP1
FBP2
FRAT2
GALNT12
HEMGN
HRAS
HSD17B3
IGFBP3
LEF1
MAP2K1
MLH1
MSANTD3
MSH4
MSH5
NANS
PCNA
PPP2CB
PPP3R2
RASA1
SEC61B
SFRP2
SMAD1
STX17
TBC1D2
TDRD7
TGFB1
TMEFF1
TMOD1
TRIM55
TRIM63
TSTD2
XPA
ZDHHC17
ZNF510
Entrez ID
5516
27030
HPRD ID
01487
05094
Ensembl ID
ENSG00000104695
ENSG00000119684
Uniprot IDs
A0A140VJS0
P62714
Q2M1Z1
Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Mismatch Repair Complex
Cellular Response To Growth Factor Stimulus
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Response To Growth Factor
MAPK Cascade
Kinase Activity
Mismatched DNA Binding
Regulation Of Protein Modification Process
Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Positive Regulation Of Signal Transduction
Enzyme Binding
Chiasma
Intracellular Signaling Cassette
Positive Regulation Of Multicellular Organismal Process
Cytosol
Regulation Of Multicellular Organismal Process
ATP-dependent DNA Damage Sensor Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of MAPK Cascade
MutLalpha Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signal Transduction
ERBB2 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
ATP Binding
Immune Response-activating Signaling Pathway
Regulation Of Neurogenesis
Regulation Of MAPK Cascade
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Morphogenesis Of A Branching Epithelium
Positive Regulation Of Immune Response
Positive Regulation Of Protein Modification Process
Animal Organ Morphogenesis
Anatomical Structure Morphogenesis
Regulation Of Protein Phosphorylation
Regulation Of Developmental Process
Phosphorylation
Gland Morphogenesis
Morphogenesis Of A Branching Structure
Mismatch Repair
Cell Development
Nucleotide Binding
Negative Regulation Of Cellular Component Organization
Transferase Activity
Mismatch Repair
Fructose 1,6-bisphosphate Metabolic Process
Mismatched DNA Binding
Fructose Metabolic Process
Canonical Wnt Signaling Pathway
Phosphoric Ester Hydrolase Activity
Fructose 1,6-bisphosphate 1-phosphatase Activity
Reproductive Process
Gluconeogenesis
Carbohydrate Biosynthetic Process
ATP-dependent DNA Damage Sensor Activity
Hexose Biosynthetic Process
Positive Regulation Of MiRNA Metabolic Process
Positive Regulation Of Deoxyribonuclease Activity
Regulation Of Protein Localization To Synapse
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Protein Localization To Cell Periphery
Insulin-like Growth Factor Receptor Signaling Pathway
Enzyme Binding
Regulation Of Protein Localization To Membrane
Negative Regulation Of Phosphate Metabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Regulation Of MiRNA Metabolic Process
DNA Repair
Cellular Response To Radiation
Positive Regulation Of Isotype Switching To IgA Isotypes
Cell Population Proliferation
DNA Metabolic Process
Small Molecule Biosynthetic Process
Neural Tube Development
Cellular Response To Stress
Somatic Cell DNA Recombination
Negative Regulation Of Small Molecule Metabolic Process
Regulation Of Small Molecule Metabolic Process
Regulation Of Ras Protein Signal Transduction
Response To Steroid Hormone
Response To Ketone
Meiotic Cell Cycle
Tube Development
Male Germ Cell Nucleus
Negative Regulation Of Striated Muscle Tissue Development
Glucose Metabolic Process
Osteoblast Differentiation
Response To Stress
Regulation Of Generation Of Precursor Metabolites And Energy
Response To Oxidative Stress
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of MiRNA Transcription
MAPK Cascade
Animal Organ Regeneration
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