PPP2CB and GAD1

Number of citations of the paper that reports this interaction (PMID 15147202)
7

Data Source:
HPRD (in vitro)

		PPP2CB	GAD1
Gene Name		protein phosphatase 2, catalytic subunit, beta isozyme	glutamate decarboxylase 1 (brain, 67kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Cytosol Extracellular Vesicular Exosome	Intracellular Plasma Membrane Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Protein Dephosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Neurotransmitter Biosynthetic Process Response To Drug
Pathways		Signaling by GPCR Integration of energy metabolism Signaling by FGFR in disease Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases ERK/MAPK targets Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Spry regulation of FGF signaling Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Signaling by FGFR Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)	Neurotransmitter Release Cycle GABA synthesis GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses
Drugs			Pyridoxal Phosphate L-Glutamic Acid
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ACP5 AXIN1 C22orf39 DOCK7 GAD1 GSTA1 HK3 LCMT1 MAK MAPT MID1 PACS1 PLXNA3 PRKCB RAF1 RELA RPLP1 SGOL1 TAB1 TAB2 TCTEX1D2 TIPRL TLX1 TRMT61B ZFP28 ZNF775	9 interactors: AGTRAP CMTM5 GAD2 HAAO PPP2CA PPP2CB PRKACA PRKCE STK3
Entrez ID		5516	2571
HPRD ID		01487	12011
Ensembl ID		ENSG00000104695	ENSG00000128683
Uniprot IDs		P62714	Q8IVA8 Q99259
PDB IDs			2OKJ 3VP6
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Positive Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway MAPK Cascade Immune Response-regulating Signaling Pathway JNK Cascade Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of MAPK Cascade Pattern Recognition Receptor Signaling Pathway Organ Development Innate Immune Response-activating Signal Transduction Anatomical Structure Morphogenesis Antigen Receptor-mediated Signaling Pathway Regulation Of Metabolic Process Activation Of MAPK Activity Activation Of Innate Immune Response Regulation Of Phosphorus Metabolic Process Generation Of Neurons Positive Regulation Of Protein Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Neuron Differentiation Cytoskeleton Organization	Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Inactivation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Activation Of Phospholipase C Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Phospholipase C Activity Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Nuclear Envelope Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cellular Glucuronidation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Epithelial Cell Migration Negative Regulation Of MAP Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of MAPK Cascade Dicarboxylic Acid Metabolic Process Positive Regulation Of Protein Kinase Activity Response To Inorganic Substance Negative Regulation Of Signaling Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Glutamate Decarboxylation To Succinate TRAM-dependent Toll-like Receptor 4 Signaling Pathway Histone H3-T6 Phosphorylation Regulation Of Receptor Activity Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Cellular Amino Acid Catabolic Process Nucleus Organization Signaling Response To Hydrogen Peroxide
Tagcloud ?			ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Difference) ?			ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Intersection) ?