PPP2CB and LCMT1

Number of citations of the paper that reports this interaction (PubMedID 10600115)
0

Data Source:
HPRD (in vitro)

		PPP2CB	LCMT1
Description		protein phosphatase 2 catalytic subunit beta	leucine carboxyl methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton FAR/SIN/STRIPAK Complex	Nucleoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Transmembrane Transporter Binding Metal Ion Binding Tau Protein Binding	Protein C-terminal Carboxyl O-methyltransferase Activity Protein Binding Methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein C-terminal Leucine Carboxyl O-methyltransferase Activity
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Microtubule Polymerization Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Regulation Of Neurofibrillary Tangle Assembly	G2/M Transition Of Mitotic Cell Cycle Protein Methylation C-terminal Protein Methylation Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Protein-containing Complex Assembly Methylation Protein Modification Process Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling	Cyclin A/B1/B2 associated events during G2/M transition
Drugs		Vitamin E	Leucine
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Heel bone mineral density x serum urate levels interaction ( 34046847)	Lead levels ( 26025379)
Interacting Genes		41 interacting genes: ACP5 AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B UBC ZFP28 ZNF775	5 interacting genes: BRCA1 CFTR FXR2 PPP2CB TAB1
Entrez ID		5516	51451
HPRD ID		01487	17266
Ensembl ID		ENSG00000104695	ENSG00000205629
Uniprot IDs		A0A140VJS0 P62714	Q9UIC8
PDB IDs			3IEI 3O7W 3P71
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mismatch Repair Complex Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Response To Growth Factor MAPK Cascade Kinase Activity Mismatched DNA Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Enzyme Binding Chiasma Intracellular Signaling Cassette Positive Regulation Of Multicellular Organismal Process Cytosol Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MutLalpha Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Protein Phosphorylation ATP Binding Immune Response-activating Signaling Pathway Regulation Of Neurogenesis Regulation Of MAPK Cascade Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Morphogenesis Of A Branching Epithelium Positive Regulation Of Immune Response Positive Regulation Of Protein Modification Process Animal Organ Morphogenesis Anatomical Structure Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Developmental Process Phosphorylation Gland Morphogenesis Morphogenesis Of A Branching Structure Mismatch Repair Cell Development Nucleotide Binding Negative Regulation Of Cellular Component Organization Transferase Activity	Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Cell Communication Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Regulation Of Signaling Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Serine/threonine Phosphatase Activity Protein-containing Complex Positive Regulation Of Monoatomic Anion Transport Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Centriole Replication Regulation Of Microtubule-based Process BRCA1-A Complex BRCA1-B Complex Embryo Development Ending In Birth Or Egg Hatching Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Multicellular Organism Development BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Response To Indole-3-methanol Response To Alcohol Chordate Embryonic Development Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Neurofibrillary Tangle Assembly Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Gene Expression Amelogenesis Positive Regulation Of Long-term Neuronal Synaptic Plasticity Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Gene Expression Gamma-tubulin Ring Complex Negative Regulation Of Centrosome Duplication Regulation Of Multicellular Organismal Process Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
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