PPP2CB and DYNLT2B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PPP2CB	DYNLT2B
Description		protein phosphatase 2 catalytic subunit beta	dynein light chain Tctex-type 2B
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton FAR/SIN/STRIPAK Complex	Spindle Pole Cytoplasm Centrosome Cytoplasmic Dynein Complex Cilium Axoneme Interphase Microtubule Organizing Center Ciliary Base Dynein Axonemal Particle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Transmembrane Transporter Binding Metal Ion Binding Tau Protein Binding	Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Microtubule Polymerization Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Regulation Of Neurofibrillary Tangle Assembly	Microtubule-based Movement Intraciliary Retrograde Transport Cilium Assembly Regulation Of Cilium Assembly Regulation Of Intraciliary Retrograde Transport
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling	Intraflagellar transport
Drugs		Vitamin E
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		41 interacting genes: ACP5 AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B UBC ZFP28 ZNF775	9 interacting genes: ACTN2 BRCA1 CDKN2D CSNK2B GTF2F2 PPP2CB TK1 TRIM55 TRIM63
Entrez ID		5516	255758
HPRD ID		01487	14554
Ensembl ID		ENSG00000104695	ENSG00000213123
Uniprot IDs		A0A140VJS0 P62714	Q8WW35
PDB IDs			8J07 8RGI
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mismatch Repair Complex Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Response To Growth Factor MAPK Cascade Kinase Activity Mismatched DNA Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Enzyme Binding Chiasma Intracellular Signaling Cassette Positive Regulation Of Multicellular Organismal Process Cytosol Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MutLalpha Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Protein Phosphorylation ATP Binding Immune Response-activating Signaling Pathway Regulation Of Neurogenesis Regulation Of MAPK Cascade Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Morphogenesis Of A Branching Epithelium Positive Regulation Of Immune Response Positive Regulation Of Protein Modification Process Animal Organ Morphogenesis Anatomical Structure Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Developmental Process Phosphorylation Gland Morphogenesis Morphogenesis Of A Branching Structure Mismatch Repair Cell Development Nucleotide Binding Negative Regulation Of Cellular Component Organization Transferase Activity	Titin Binding Transmembrane Transporter Binding Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Cytoskeleton Organization Channel Activator Activity Metal Ion Binding Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Z Disc Identical Protein Binding LIM Domain Binding Protein Modification Process Negative Regulation Of Centriole Replication BRCA1-B Complex Negative Regulation Of Cell Growth Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Small Molecule Metabolic Process Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Nucleus Negative Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Histone H2AK129 Ubiquitin Ligase Activity Macromolecule Metabolic Process Response To Indole-3-methanol BRCA1-BARD1 Complex Protein Ubiquitination Cyclin D2-CDK4 Complex DNA Biosynthetic Process Autophagic Cell Death Positive Regulation Of Activin Receptor Signaling Pathway Protein Kinase CK2 Complex Negative Regulation Of Viral Life Cycle Symbiont-mediated Disruption Of Host Cell PML Body Release From Viral Latency RNA Polymerase II, Holoenzyme Transcription Factor TFIIF Complex Regulation Of Neurofibrillary Tangle Assembly DNA Synthesis Involved In Mitotic DNA Replication Thymidine Metabolic Process Thymidine Biosynthetic Process Thymidine Kinase Activity Diapedesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy
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