PPP2CB and PMS2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PPP2CB	PMS2
Description		protein phosphatase 2 catalytic subunit beta	PMS1 homolog 2, mismatch repair system component
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton FAR/SIN/STRIPAK Complex	Nucleus Nucleoplasm Cytosol Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Transmembrane Transporter Binding Metal Ion Binding Tau Protein Binding	Nucleotide Binding DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Mismatched DNA Binding Single Base Insertion Or Deletion Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Microtubule Polymerization Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Regulation Of Neurofibrillary Tangle Assembly	DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs		Vitamin E	Adenosine 5'-[gamma-thio]triphosphate
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Daytime sleep phenotypes ( 27126917) Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		41 interacting genes: ACP5 AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B UBC ZFP28 ZNF775	18 interacting genes: AKT1 ANP32B CCDC180 CRYAA EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC VPS26C XPA ZNF189
Entrez ID		5516	5395
HPRD ID		01487	02598
Ensembl ID		ENSG00000104695	ENSG00000122512
Uniprot IDs		A0A140VJS0 P62714	A0A2R8Y6S3 A0A8V8TNX6 A0A8V8TNY8 A0A8V8TP61 A0A8V8TP84 A0A8V8TPE1 A0A8V8TQ50 A0A8V8TQ92 A0A8V8TQG9 A0A8V8TQI1 A0A8V8TQS5 B4DGM0 C9J167 P54278
PDB IDs			1EA6 1H7S 1H7U 5U5R 6MFQ 7RCB 7RCI 7RCK
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mismatch Repair Complex Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Response To Growth Factor MAPK Cascade Kinase Activity Mismatched DNA Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Enzyme Binding Chiasma Intracellular Signaling Cassette Positive Regulation Of Multicellular Organismal Process Cytosol Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MutLalpha Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Protein Phosphorylation ATP Binding Immune Response-activating Signaling Pathway Regulation Of Neurogenesis Regulation Of MAPK Cascade Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Morphogenesis Of A Branching Epithelium Positive Regulation Of Immune Response Positive Regulation Of Protein Modification Process Animal Organ Morphogenesis Anatomical Structure Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Developmental Process Phosphorylation Gland Morphogenesis Morphogenesis Of A Branching Structure Mismatch Repair Cell Development Nucleotide Binding Negative Regulation Of Cellular Component Organization Transferase Activity	Response To Oxidative Stress Positive Regulation Of Deoxyribonuclease Activity Mismatch Repair Response To UV Response To UV-A Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Hydrogen Peroxide DNA Repair Response To Light Stimulus Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Stress Enzyme Binding TRNA Methylation Nucleus Regulation Of TRNA Methylation Response To Radiation Response To Reactive Oxygen Species DNA Metabolic Process DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Late Recombination Nodule Somatic Diversification Of Immunoglobulins Meiotic Metaphase I Homologous Chromosome Alignment PCNA Complex Replisome Negative Regulation Of Sodium-dependent Phosphate Transport Nucleotide-excision Repair, DNA Damage Recognition Double-stranded DNA 5'-3' DNA Exonuclease Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity Male Germ Cell Nucleus Nucleotide-excision Repair
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